MSC-sEVs exacerbate senescence by transferring bisecting GlcNAcylated GPNMB

MSC-sEVs exacerbate senescence by transferring bisecting GlcNAcylated GPNMB

Abstract Background The senescence of bone marrow mesenchymal stem cells (BMMSCs) is increasingly recognized as a critical factor contributing to the pathophysiology of age-related diseases. Recent studies suggest that small extracellular vesicles (sEVs) derived from the serum of elderly individuals...

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Bibliographic Details
Main Authors: Yihan Ma, Chongfu Zhao, Jingjing Feng, Junjie Gou, Enci Kang, Feng Guan, Qiong Wu, Xiang Li
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Stem Cell Research & Therapy
Subjects:
Bisecting GlcNAc
GPNMB
Bone marrow mesenchymal stem cells
Small extracellular vesicles
Senescence
Online Access:https://doi.org/10.1186/s13287-025-04140-9
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