TGF-β signaling orchestrates cancer-associated fibroblasts in the tumor microenvironment of human hepatocellular carcinoma: unveiling insights and clinical significance

TGF-β signaling orchestrates cancer-associated fibroblasts in the tumor microenvironment of human hepatocellular carcinoma: unveiling insights and clinical significance

Abstract Liver cancer, specifically hepatocellular carcinoma (HCC), stands out as one of the most formidable solid tumors, characterized by a dauntingly low survival rate. At the forefront of the tumor microenvironment (TME) orchestrating the initiation and advancement of HCC are cancer-associated f...

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Bibliographic Details
Main Authors:	Junwei Ge, Hongwei Jiang, Junjun Chen, Xuemin Chen, Yue Zhang, Liangrong Shi, Xiao Zheng, Jingting Jiang, Lujun Chen
Format:	Article
Language:	English
Published:	BMC 2025-01-01
Series:	BMC Cancer
Subjects:	Hepatocellular carcinoma Multi-color immunohistochemistry TGF-β iCAF myCAF
Online Access:	https://doi.org/10.1186/s12885-025-13435-2
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