Endophytic fungi isolated from Vietnamese nut grass (Cyperus rotundus L. Cyperaceae) – A promising solution to mitigate the prime phenomenon of antibiotic resistance
Multidrug resistance in bacteria poses a significant threat to global health, creating an urgent need for new sources of antibiotics. Nut grass or Cyperus rotundus L., a common Asian medicinal herbal remedy, is gaining increasing attention in the scientific community as a potential source of antimic...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025003007 |
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| author | Bac V.G. Nguyen Linh X.T. Tran Anh-Tu Ha-Nguyen Minh-Tri Le Thanh-Hoa Vo Gia Phong Vu Phuoc-Vinh Nguyen |
| author_facet | Bac V.G. Nguyen Linh X.T. Tran Anh-Tu Ha-Nguyen Minh-Tri Le Thanh-Hoa Vo Gia Phong Vu Phuoc-Vinh Nguyen |
| author_sort | Bac V.G. Nguyen |
| collection | DOAJ |
| description | Multidrug resistance in bacteria poses a significant threat to global health, creating an urgent need for new sources of antibiotics. Nut grass or Cyperus rotundus L., a common Asian medicinal herbal remedy, is gaining increasing attention in the scientific community as a potential source of antimicrobial agents. In this study, endophytic fungi living in this plant were isolated, macro- and micrologically identified, and assessed for their antibacterial properties on both Gram-positive and Gram-negative bacteria. As a result, seven types of endophytic fungi with potential antibacterial activities were obtained from Vietnamese Cyperus rotundus L. These endophytic strains could inhibit Gram-positive bacteria, including Bacillus subtilis, Methicilin-susceptible Staphylococcus aureus (MSSA), and Methicilin-resistant Staphylococcus aureus (MRSA). In particular, the most potent fungus could effectively inhibit not only MRSA but also Escherichia coli, and Pseudomonas aeruginosa. Furthermore, a significant impact of the culture medium on the biomass’ antibacterial activity was observed and the Potato Dextrose Agar (PDA) and Czapek-Dox (Cz) media were shown to be the most appropriate culture medium. Altogether, endophytic fungi isolated from Cyperus rotundus L. were shown to be a promising source for antibiotics to tackle the problem of antibiotic resistance. |
| format | Article |
| id | doaj-art-26da8f36fb5a40b0a94d7678b4e6a6a0 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-26da8f36fb5a40b0a94d7678b4e6a6a02025-01-28T04:14:44ZengElsevierHeliyon2405-84402025-02-01113e41920Endophytic fungi isolated from Vietnamese nut grass (Cyperus rotundus L. Cyperaceae) – A promising solution to mitigate the prime phenomenon of antibiotic resistanceBac V.G. Nguyen0Linh X.T. Tran1Anh-Tu Ha-Nguyen2Minh-Tri Le3Thanh-Hoa Vo4Gia Phong Vu5Phuoc-Vinh Nguyen6Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet NamFaculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet NamUniversity of Health Sciences, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Viet NamFaculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam; University of Health Sciences, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Viet NamUniversity of Health Sciences, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Viet NamHong Bang International University, Ho Chi Minh City, Viet NamUniversity of Health Sciences, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Research Center of Discovery and Development of Healthcare Products Vietnam National University Ho Chi Minh City, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Corresponding author. University of Health Sciences, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Viet Nam.Multidrug resistance in bacteria poses a significant threat to global health, creating an urgent need for new sources of antibiotics. Nut grass or Cyperus rotundus L., a common Asian medicinal herbal remedy, is gaining increasing attention in the scientific community as a potential source of antimicrobial agents. In this study, endophytic fungi living in this plant were isolated, macro- and micrologically identified, and assessed for their antibacterial properties on both Gram-positive and Gram-negative bacteria. As a result, seven types of endophytic fungi with potential antibacterial activities were obtained from Vietnamese Cyperus rotundus L. These endophytic strains could inhibit Gram-positive bacteria, including Bacillus subtilis, Methicilin-susceptible Staphylococcus aureus (MSSA), and Methicilin-resistant Staphylococcus aureus (MRSA). In particular, the most potent fungus could effectively inhibit not only MRSA but also Escherichia coli, and Pseudomonas aeruginosa. Furthermore, a significant impact of the culture medium on the biomass’ antibacterial activity was observed and the Potato Dextrose Agar (PDA) and Czapek-Dox (Cz) media were shown to be the most appropriate culture medium. Altogether, endophytic fungi isolated from Cyperus rotundus L. were shown to be a promising source for antibiotics to tackle the problem of antibiotic resistance.http://www.sciencedirect.com/science/article/pii/S2405844025003007Cyperus rotundus L.Endophytic fungiAntibioticsMultidrug resistance |
| spellingShingle | Bac V.G. Nguyen Linh X.T. Tran Anh-Tu Ha-Nguyen Minh-Tri Le Thanh-Hoa Vo Gia Phong Vu Phuoc-Vinh Nguyen Endophytic fungi isolated from Vietnamese nut grass (Cyperus rotundus L. Cyperaceae) – A promising solution to mitigate the prime phenomenon of antibiotic resistance Heliyon Cyperus rotundus L. Endophytic fungi Antibiotics Multidrug resistance |
| title | Endophytic fungi isolated from Vietnamese nut grass (Cyperus rotundus L. Cyperaceae) – A promising solution to mitigate the prime phenomenon of antibiotic resistance |
| title_full | Endophytic fungi isolated from Vietnamese nut grass (Cyperus rotundus L. Cyperaceae) – A promising solution to mitigate the prime phenomenon of antibiotic resistance |
| title_fullStr | Endophytic fungi isolated from Vietnamese nut grass (Cyperus rotundus L. Cyperaceae) – A promising solution to mitigate the prime phenomenon of antibiotic resistance |
| title_full_unstemmed | Endophytic fungi isolated from Vietnamese nut grass (Cyperus rotundus L. Cyperaceae) – A promising solution to mitigate the prime phenomenon of antibiotic resistance |
| title_short | Endophytic fungi isolated from Vietnamese nut grass (Cyperus rotundus L. Cyperaceae) – A promising solution to mitigate the prime phenomenon of antibiotic resistance |
| title_sort | endophytic fungi isolated from vietnamese nut grass cyperus rotundus l cyperaceae a promising solution to mitigate the prime phenomenon of antibiotic resistance |
| topic | Cyperus rotundus L. Endophytic fungi Antibiotics Multidrug resistance |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025003007 |
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