SPP1+ tumor-associated macrophages define a high-risk subgroup and inform personalized therapy in hepatocellular carcinoma

SPP1+ tumor-associated macrophages define a high-risk subgroup and inform personalized therapy in hepatocellular carcinoma

IntroductionRecently, contrary to attacking cancer cells, the tumor microenvironment (TME) with genomic stability and vulnerable nature has emerged as promising therapeutic targets in hepatocellular carcinoma (HCC). Within TME ecosystem, tumor-associated macrophages (TAMs) play a pivotal role in tum...

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Bibliographic Details
Main Authors: Wei-Xuan Xu, Ya-Mei Ye, Jia-Lin Chen, Xin-Ying Guo, Chen Li, Juan Luo, Lin-Bin Lu, Xiong Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Oncology
Subjects:
hepatocellular carcinoma
tumor-associated macrophages
single-cell RNA-seq
patient stratification
clinical treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1606195/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1606195/full

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