Three Huntington's Disease Specific Mutation-Carrying Human Embryonic Stem Cell Lines Have Stable Number of CAG Repeats upon In Vitro Differentiation into Cardiomyocytes.

Three Huntington's Disease Specific Mutation-Carrying Human Embryonic Stem Cell Lines Have Stable Number of CAG Repeats upon In Vitro Differentiation into Cardiomyocytes.

Huntington disease (HD; OMIM 143100), a progressive neurodegenerative disorder, is caused by an expanded trinucleotide CAG (polyQ) motif in the HTT gene. Cardiovascular symptoms, often present in early stage HD patients, are, in general, ascribed to dysautonomia. However, cardio-specific expression...

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Main Authors: Laureen Jacquet, Andreas Neueder, Gabor Földes, Panagiotis Karagiannis, Carl Hobbs, Nelly Jolinon, Maxime Mioulane, Takao Sakai, Sian E Harding, Dusko Ilic
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0126860&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0126860&type=printable

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