Different Stability and Proteasome-Mediated Degradation Rate of SMN Protein Isoforms.

Different Stability and Proteasome-Mediated Degradation Rate of SMN Protein Isoforms.

The key pathogenic steps leading to spinal muscular atrophy (SMA), a genetic disease characterized by selective motor neuron degeneration, are not fully clarified. The full-length SMN protein (FL-SMN), the main protein product of the disease gene SMN1, plays an established role in the cytoplasm in s...

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Main Authors: Denise Locatelli, Mineko Terao, Mami Kurosaki, Maria Clara Zanellati, Daniela Rita Pletto, Adele Finardi, Francesca Colciaghi, Enrico Garattini, Giorgio Stefano Battaglia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0134163&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0134163&type=printable

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