Ubiquitin-activating enzyme1 (TgUAE1) acts as a key regulator of Toxoplasma gondii lytic cycle and homeostasis

Abstract Ubiquitylation, regulated by the ubiquitin-proteasome system (UPS), is crucial for cell division and cycle transitions in Toxoplasma gondii. However, the primary E1 ubiquitin-activating enzyme (UAE1) in this process has been unclear. This study identified and characterized TGGT1_290290 (TgU...

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Bibliographic Details
Main Authors: Qi-xin Zhou, Dai-qiang Lu, Si-yu Tian, Yao Lv, Ming-wei Chen, Xin Tian, Yan-tao Wu, Fang-jun Luo, Feng Tan, Ya-ni Mou
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08149-x
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