Exonic sequencing identifies TLR1 genetic variation associated with mortality in Thais with melioidosis

Exonic sequencing identifies TLR1 genetic variation associated with mortality in Thais with melioidosis

Melioidosis, an infectious disease caused by the bacterium Burkholderia pseudomallei, is a common cause of sepsis in Southeast Asia. We investigated whether novel TLR1 coding variants are associated with outcome in Thai patients with melioidosis. We performed exonic sequencing on a discovery set of...

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Bibliographic Details
Main Authors: Shelton W. Wright, Mary J. Emond, Lara Lovelace-Macon, Deirdre Ducken, James Kashima, Viriya Hantrakun, Wirongrong Chierakul, Prapit Teparrukkul, Narisara Chantratita, Direk Limmathurotsakul, T. Eoin West
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Emerging Microbes and Infections
Subjects:
TLR1
melioidosis
sepsis
genetic variation
Burkholderia pseudomallei
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2019.1575172
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https://www.tandfonline.com/doi/10.1080/22221751.2019.1575172

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