An Overview of Long Noncoding RNAs Involved in Bone Regeneration from Mesenchymal Stem Cells
Bone regeneration is very important for the recovery of some diseases including osteoporosis and bone fracture trauma. It is a multiple-step- and multiple-gene-involved complex process, including the matrix secretion and calcium mineralization by osteoblasts differentiated from mesenchymal stem cell...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/8273648 |
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| _version_ | 1832551790885732352 |
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| author | Shuping Peng Lihua Cao Shiwei He Yancheng Zhong Haotian Ma Yanru Zhang Cijun Shuai |
| author_facet | Shuping Peng Lihua Cao Shiwei He Yancheng Zhong Haotian Ma Yanru Zhang Cijun Shuai |
| author_sort | Shuping Peng |
| collection | DOAJ |
| description | Bone regeneration is very important for the recovery of some diseases including osteoporosis and bone fracture trauma. It is a multiple-step- and multiple-gene-involved complex process, including the matrix secretion and calcium mineralization by osteoblasts differentiated from mesenchymal stem cells (MSCs) and the absorption of calcium and phosphorus by osteoclasts differentiated from hematopoietic stem cells. Long noncoding RNAs (lncRNAs) are a family of transcripts longer than 200 nt without or with very low protein-coding potential. Recent studies have demonstrated that lncRNAs are widely involved in the regulation of lineage commitment and differentiation of stem cells through multiple mechanisms. In this review, we will summarize the roles and molecular mechanism of lncRNAs including H19, MALAT1, MODR, HOTAIR, DANCR, MEG3, HoxA-AS3, and MIAT in osteogenesis ossification; lncRNA ZBED3-AS1 and CTA-941F9.9, DANCR, and HIT in chondrogenic differentiation; and lncRNA DANCR in osteoclast differentiation. These findings will facilitate the development and application of novel molecular drugs which regulate the balance of bone formation and absorption. |
| format | Article |
| id | doaj-art-261c01ac42d849ee91640a1a0fe0ced7 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-261c01ac42d849ee91640a1a0fe0ced72025-02-03T06:00:30ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/82736488273648An Overview of Long Noncoding RNAs Involved in Bone Regeneration from Mesenchymal Stem CellsShuping Peng0Lihua Cao1Shiwei He2Yancheng Zhong3Haotian Ma4Yanru Zhang5Cijun Shuai6Hunan Provincial Tumor Hospital and The Affiliated Tumor Hospital of Xiangya School of Medicine, Basic Medicine College, Central South University, Changsha 410013, ChinaHunan Provincial Tumor Hospital and The Affiliated Tumor Hospital of Xiangya School of Medicine, Basic Medicine College, Central South University, Changsha 410013, ChinaHunan Provincial Tumor Hospital and The Affiliated Tumor Hospital of Xiangya School of Medicine, Basic Medicine College, Central South University, Changsha 410013, ChinaHunan Provincial Tumor Hospital and The Affiliated Tumor Hospital of Xiangya School of Medicine, Basic Medicine College, Central South University, Changsha 410013, ChinaHunan Provincial Tumor Hospital and The Affiliated Tumor Hospital of Xiangya School of Medicine, Basic Medicine College, Central South University, Changsha 410013, ChinaHunan Provincial Tumor Hospital and The Affiliated Tumor Hospital of Xiangya School of Medicine, Basic Medicine College, Central South University, Changsha 410013, ChinaSchool of Energy and Mechanical Engineering, Jiangxi University of Science and Technology, Nanchang, Jiangxi, ChinaBone regeneration is very important for the recovery of some diseases including osteoporosis and bone fracture trauma. It is a multiple-step- and multiple-gene-involved complex process, including the matrix secretion and calcium mineralization by osteoblasts differentiated from mesenchymal stem cells (MSCs) and the absorption of calcium and phosphorus by osteoclasts differentiated from hematopoietic stem cells. Long noncoding RNAs (lncRNAs) are a family of transcripts longer than 200 nt without or with very low protein-coding potential. Recent studies have demonstrated that lncRNAs are widely involved in the regulation of lineage commitment and differentiation of stem cells through multiple mechanisms. In this review, we will summarize the roles and molecular mechanism of lncRNAs including H19, MALAT1, MODR, HOTAIR, DANCR, MEG3, HoxA-AS3, and MIAT in osteogenesis ossification; lncRNA ZBED3-AS1 and CTA-941F9.9, DANCR, and HIT in chondrogenic differentiation; and lncRNA DANCR in osteoclast differentiation. These findings will facilitate the development and application of novel molecular drugs which regulate the balance of bone formation and absorption.http://dx.doi.org/10.1155/2018/8273648 |
| spellingShingle | Shuping Peng Lihua Cao Shiwei He Yancheng Zhong Haotian Ma Yanru Zhang Cijun Shuai An Overview of Long Noncoding RNAs Involved in Bone Regeneration from Mesenchymal Stem Cells Stem Cells International |
| title | An Overview of Long Noncoding RNAs Involved in Bone Regeneration from Mesenchymal Stem Cells |
| title_full | An Overview of Long Noncoding RNAs Involved in Bone Regeneration from Mesenchymal Stem Cells |
| title_fullStr | An Overview of Long Noncoding RNAs Involved in Bone Regeneration from Mesenchymal Stem Cells |
| title_full_unstemmed | An Overview of Long Noncoding RNAs Involved in Bone Regeneration from Mesenchymal Stem Cells |
| title_short | An Overview of Long Noncoding RNAs Involved in Bone Regeneration from Mesenchymal Stem Cells |
| title_sort | overview of long noncoding rnas involved in bone regeneration from mesenchymal stem cells |
| url | http://dx.doi.org/10.1155/2018/8273648 |
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