Emerging targets of α-synuclein spreading in α-synucleinopathies: a review of mechanistic pathways and interventions

Emerging targets of α-synuclein spreading in α-synucleinopathies: a review of mechanistic pathways and interventions

Abstract α-Synucleinopathies constitute a spectrum of neurodegenerative disorders, including Parkinson’s disease (PD), Lewy body dementia (LBD), Multiple System Atrophy (MSA), and Alzheimer’s disease concurrent with LBD (AD-LBD). These disorders are unified by a pathological hallmark: aberrant misfo...

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Bibliographic Details
Main Authors: Grace Kuo, Ramhari Kumbhar, William Blair, Valina L. Dawson, Ted M. Dawson, Xiaobo Mao
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Molecular Neurodegeneration
Subjects:
Prion-like
α-synuclein
Spreading
Receptor
Therapeutic targets
Online Access:https://doi.org/10.1186/s13024-025-00797-1
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