Exploring the pathway: clinical utility and open challenges of targeting BRAF alterations in biliary tract cancers and gastrointestinal malignancies

Exploring the pathway: clinical utility and open challenges of targeting BRAF alterations in biliary tract cancers and gastrointestinal malignancies

The BRAF proto-oncogene plays a key role in oncogenesis, promoting growth and survival through various genetic alterations. Most mutations involve the substitution of valine at amino acid position 600 (V600), resulting in a constitutively active protein, known as class I alterations. The most common...

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Bibliographic Details
Main Authors: L. Weiss, D. Zhang, W.G. Kunz, S. Boeck, G. Curigliano, V. Subbiah, F. Lordick, T. Brummer, C.B. Westphalen, L. Boscolo Bielo
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:ESMO Gastrointestinal Oncology
Subjects:
biliary tract cancers
BRAF
BRAF V600E
gastrointestinal cancers
precision oncology
targeted therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2949819824000906
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