Interplay between sarcopenia, GDF-15, and the efficacy of nivolumab plus ipilimumab in patients with mismatch repair deficient metastatic colorectal cancer: final survival analysis of the phase II GERCOR NIPICOL study

Interplay between sarcopenia, GDF-15, and the efficacy of nivolumab plus ipilimumab in patients with mismatch repair deficient metastatic colorectal cancer: final survival analysis of the phase II GERCOR NIPICOL study

Background Sarcopenia and growth differentiation factor 15 (GDF-15) are linked to poor cancer survival. In this exploratory analysis, we evaluated their interaction with nivolumab-ipilimumab efficacy in chemoresistant metastatic colorectal cancer (mCRC) harboring microsatellite instability and/or mi...

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Main Authors: Christelle de La Fouchardière, Jaafar Bennouna, David Tougeron, Thierry André, Christophe Tournigand, Christophe Borg, Romain Cohen, Thibault Mazard, Dewi Vernerey, Frédéric Pigneur, Julie Henriques, Aurélia Meurisse, Benoist Chibaudel, Leonard Depotte, Paula Nay
Format: Article
Language:English
Published: BMJ Publishing Group 2025-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/5/e011220.full
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https://jitc.bmj.com/content/13/5/e011220.full

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