Electrospun Polycaprolactone (PCL) Nanofibers Induce Elongation and Alignment of Co-Cultured Primary Cortical Astrocytes and Neurons

Electrospun Polycaprolactone (PCL) Nanofibers Induce Elongation and Alignment of Co-Cultured Primary Cortical Astrocytes and Neurons

Neuromimetic in vitro models, simulating in vivo architecture/organization, are urgently needed to reduce experimental reliance on live animals. Our group recently reported a novel brain tissue derivation protocol, simultaneously deriving all major cortical cell types (including immune cells) in a f...

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Bibliographic Details
Main Authors: Kayleigh Nutt, Zoe Dombros-Ryan, Ruxandra Birea, Emily Victoria Franks, Sarah Eastham, Morgan Godwin, Chris F. Adams, Divya Maitreyi Chari, Stuart Iain Jenkins
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Micromachines
Subjects:
microfibers
nanofibers
brain
biomaterials
polymers
electrospinning
Online Access:https://www.mdpi.com/2072-666X/16/3/256
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