New Insights into Artesunate as a Pleiotropic Regulator of Innate and Adaptive Immune Cells
Artesunate, one of the derivatives of artemisinin (“qinghaosu” in Chinese), is known as an antimalarial drug with high efficiency and low toxicity. Of interest, emerging evidences suggest that artesunate also possesses an immunomodulatory effect during innate and adaptive immune responses in cell ty...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/9591544 |
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| author | Lixian Lin Zengqi Tang Zhenrui Shi Qing Guo Hui Xiong |
| author_facet | Lixian Lin Zengqi Tang Zhenrui Shi Qing Guo Hui Xiong |
| author_sort | Lixian Lin |
| collection | DOAJ |
| description | Artesunate, one of the derivatives of artemisinin (“qinghaosu” in Chinese), is known as an antimalarial drug with high efficiency and low toxicity. Of interest, emerging evidences suggest that artesunate also possesses an immunomodulatory effect during innate and adaptive immune responses in cell types and context-dependent manner. Although it shows promising application in many diseases, such as inflammatory diseases, hypersensitivity, autoimmune diseases, and cancers, little is known about underlying molecular. In this review, we summarize recent advances of how artesunate regulates innate and adaptive immune cells. In addition, its potential application in immune-related diseases is also highlighted. |
| format | Article |
| id | doaj-art-25c1f032da03405a91c6ea6706c084c2 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-25c1f032da03405a91c6ea6706c084c22025-02-03T06:14:11ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/9591544New Insights into Artesunate as a Pleiotropic Regulator of Innate and Adaptive Immune CellsLixian Lin0Zengqi Tang1Zhenrui Shi2Qing Guo3Hui Xiong4Department of DermatologyDepartment of DermatologyDepartment of DermatologyDepartment of DermatologyDepartment of DermatologyArtesunate, one of the derivatives of artemisinin (“qinghaosu” in Chinese), is known as an antimalarial drug with high efficiency and low toxicity. Of interest, emerging evidences suggest that artesunate also possesses an immunomodulatory effect during innate and adaptive immune responses in cell types and context-dependent manner. Although it shows promising application in many diseases, such as inflammatory diseases, hypersensitivity, autoimmune diseases, and cancers, little is known about underlying molecular. In this review, we summarize recent advances of how artesunate regulates innate and adaptive immune cells. In addition, its potential application in immune-related diseases is also highlighted.http://dx.doi.org/10.1155/2022/9591544 |
| spellingShingle | Lixian Lin Zengqi Tang Zhenrui Shi Qing Guo Hui Xiong New Insights into Artesunate as a Pleiotropic Regulator of Innate and Adaptive Immune Cells Journal of Immunology Research |
| title | New Insights into Artesunate as a Pleiotropic Regulator of Innate and Adaptive Immune Cells |
| title_full | New Insights into Artesunate as a Pleiotropic Regulator of Innate and Adaptive Immune Cells |
| title_fullStr | New Insights into Artesunate as a Pleiotropic Regulator of Innate and Adaptive Immune Cells |
| title_full_unstemmed | New Insights into Artesunate as a Pleiotropic Regulator of Innate and Adaptive Immune Cells |
| title_short | New Insights into Artesunate as a Pleiotropic Regulator of Innate and Adaptive Immune Cells |
| title_sort | new insights into artesunate as a pleiotropic regulator of innate and adaptive immune cells |
| url | http://dx.doi.org/10.1155/2022/9591544 |
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