Simulators of Squamous Cell Carcinoma of the Skin: Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation
Squamous cell carcinoma (SCC) is a common and important primary cutaneous malignancy. On skin biopsies, SCC is characterized by significant squamous cell atypia, abnormal keratinization, and invasive features. Diagnostic challenges may occasionally arise, especially in the setting of small punch bio...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2013/752864 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549295167897600 |
|---|---|
| author | Kong-Bing Tan Sze-Hwa Tan Derrick Chen-Wee Aw Huma Jaffar Thiam-Chye Lim Shu-Jin Lee Yoke-Sun Lee |
| author_facet | Kong-Bing Tan Sze-Hwa Tan Derrick Chen-Wee Aw Huma Jaffar Thiam-Chye Lim Shu-Jin Lee Yoke-Sun Lee |
| author_sort | Kong-Bing Tan |
| collection | DOAJ |
| description | Squamous cell carcinoma (SCC) is a common and important primary cutaneous malignancy. On skin biopsies, SCC is characterized by significant squamous cell atypia, abnormal keratinization, and invasive features. Diagnostic challenges may occasionally arise, especially in the setting of small punch biopsies or superficial shave biopsies, where only part of the lesion may be assessable by the pathologist. Benign mimics of SCC include pseudoepitheliomatous hyperplasia, eccrine squamous syringometaplasia, inverted follicular keratosis, and keratoacanthoma, while malignant mimics of SCC include basal cell carcinoma, melanoma, and metastatic carcinoma. The careful application of time-honored diagnostic criteria, close clinicopathological correlation and a selective request for a further, deeper, or wider biopsy remain the most useful strategies to clinch the correct diagnosis. This review aims to present the key differential diagnoses of SCC, to discuss common diagnostic pitfalls, and to recommend ways to deal with diagnostically challenging cases. |
| format | Article |
| id | doaj-art-25b84c91dfc046f8a01bbbf82acfd36a |
| institution | Kabale University |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-25b84c91dfc046f8a01bbbf82acfd36a2025-02-03T06:11:37ZengWileyJournal of Skin Cancer2090-29052090-29132013-01-01201310.1155/2013/752864752864Simulators of Squamous Cell Carcinoma of the Skin: Diagnostic Challenges on Small Biopsies and Clinicopathological CorrelationKong-Bing Tan0Sze-Hwa Tan1Derrick Chen-Wee Aw2Huma Jaffar3Thiam-Chye Lim4Shu-Jin Lee5Yoke-Sun Lee6Department of Pathology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Lower Kent Ridge Road, 119074, SingaporeDepartment of Pathology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Lower Kent Ridge Road, 119074, SingaporeUniversity Medicine Cluster, National University Health System, 119074, SingaporeUniversity Medicine Cluster, National University Health System, 119074, SingaporeUniversity Surgical Cluster, National University Health System, 119074, SingaporeDepartments of Otorhinolaryngology and Hand and Reconstructive Microsurgery, National University Health System, 119074, SingaporeDepartment of Pathology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Lower Kent Ridge Road, 119074, SingaporeSquamous cell carcinoma (SCC) is a common and important primary cutaneous malignancy. On skin biopsies, SCC is characterized by significant squamous cell atypia, abnormal keratinization, and invasive features. Diagnostic challenges may occasionally arise, especially in the setting of small punch biopsies or superficial shave biopsies, where only part of the lesion may be assessable by the pathologist. Benign mimics of SCC include pseudoepitheliomatous hyperplasia, eccrine squamous syringometaplasia, inverted follicular keratosis, and keratoacanthoma, while malignant mimics of SCC include basal cell carcinoma, melanoma, and metastatic carcinoma. The careful application of time-honored diagnostic criteria, close clinicopathological correlation and a selective request for a further, deeper, or wider biopsy remain the most useful strategies to clinch the correct diagnosis. This review aims to present the key differential diagnoses of SCC, to discuss common diagnostic pitfalls, and to recommend ways to deal with diagnostically challenging cases.http://dx.doi.org/10.1155/2013/752864 |
| spellingShingle | Kong-Bing Tan Sze-Hwa Tan Derrick Chen-Wee Aw Huma Jaffar Thiam-Chye Lim Shu-Jin Lee Yoke-Sun Lee Simulators of Squamous Cell Carcinoma of the Skin: Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation Journal of Skin Cancer |
| title | Simulators of Squamous Cell Carcinoma of the Skin: Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation |
| title_full | Simulators of Squamous Cell Carcinoma of the Skin: Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation |
| title_fullStr | Simulators of Squamous Cell Carcinoma of the Skin: Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation |
| title_full_unstemmed | Simulators of Squamous Cell Carcinoma of the Skin: Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation |
| title_short | Simulators of Squamous Cell Carcinoma of the Skin: Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation |
| title_sort | simulators of squamous cell carcinoma of the skin diagnostic challenges on small biopsies and clinicopathological correlation |
| url | http://dx.doi.org/10.1155/2013/752864 |
| work_keys_str_mv | AT kongbingtan simulatorsofsquamouscellcarcinomaoftheskindiagnosticchallengesonsmallbiopsiesandclinicopathologicalcorrelation AT szehwatan simulatorsofsquamouscellcarcinomaoftheskindiagnosticchallengesonsmallbiopsiesandclinicopathologicalcorrelation AT derrickchenweeaw simulatorsofsquamouscellcarcinomaoftheskindiagnosticchallengesonsmallbiopsiesandclinicopathologicalcorrelation AT humajaffar simulatorsofsquamouscellcarcinomaoftheskindiagnosticchallengesonsmallbiopsiesandclinicopathologicalcorrelation AT thiamchyelim simulatorsofsquamouscellcarcinomaoftheskindiagnosticchallengesonsmallbiopsiesandclinicopathologicalcorrelation AT shujinlee simulatorsofsquamouscellcarcinomaoftheskindiagnosticchallengesonsmallbiopsiesandclinicopathologicalcorrelation AT yokesunlee simulatorsofsquamouscellcarcinomaoftheskindiagnosticchallengesonsmallbiopsiesandclinicopathologicalcorrelation |