Changes in the Microbiome During Chronic Rhinosinusitis
Chronic rhinosinusitis (CRS) is a common inflammatory disease of the paranasal sinuses with a yet unknown etiology. As studies continue to elucidate the disease’s heterogeneity inflammatory profile and presentation, there is a growing interest in the influence of the nasal microbiome on disease path...
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2024-12-01
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| author | Mateusz de Mezer Nina Chalama Cheyanna Bratt Melanie Kiebalo Natalia Dolata Jan Rogaliński Małgorzata Leszczyńska |
| author_facet | Mateusz de Mezer Nina Chalama Cheyanna Bratt Melanie Kiebalo Natalia Dolata Jan Rogaliński Małgorzata Leszczyńska |
| author_sort | Mateusz de Mezer |
| collection | DOAJ |
| description | Chronic rhinosinusitis (CRS) is a common inflammatory disease of the paranasal sinuses with a yet unknown etiology. As studies continue to elucidate the disease’s heterogeneity inflammatory profile and presentation, there is a growing interest in the influence of the nasal microbiome on disease pathogenesis and chronicity. The sinus microbiota appear dominated by the <i>Staphylococcus</i> and <i>Corynebacterium</i> genera; known upper airway pathogens, such as <i>Haemophilus influenza</i>, are present in the upper airways of healthy individuals, though at relatively lower abundances than in CRS patients. Viral culprits may induce an unhindered local immune response that contributes to the recurrence and chronicity of inverted papillomas—benign mucosal lesions with the propensity for local destruction and malignant transformation that can be found in patients with a history of nasal infection. The persistence of inverted papillomas warrants investigation into their pathogenesis and how they may contribute to a nasal landscape promoting the chronicity of CRS. Further investigation is needed to uncover the interplay between resident microbiota and viral, fungal, and immunological influence. Discerning between ‘healthy’ and ‘diseased’ sinonasal microbiomes and ‘keystone’ species could shed light on CRS etiology and provide the opportunity for CRS treatment tailored to an individual’s microbiome. This review aims to explore the interrelation of microbial residents in the pathogenesis and chronicity of the diseased sinonasal environment. |
| format | Article |
| id | doaj-art-25b512556a1b46b79ca6dbc11a4040e5 |
| institution | Kabale University |
| issn | 2076-0817 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| spelling | doaj-art-25b512556a1b46b79ca6dbc11a4040e52025-01-24T13:44:35ZengMDPI AGPathogens2076-08172024-12-011411410.3390/pathogens14010014Changes in the Microbiome During Chronic RhinosinusitisMateusz de Mezer0Nina Chalama1Cheyanna Bratt2Melanie Kiebalo3Natalia Dolata4Jan Rogaliński5Małgorzata Leszczyńska6Department of Immunobiology, Poznań University of Medical Sciences, Rokietnicka 8 St., 60-812 Poznań, PolandDepartment of Otolaryngology and Laryngological Oncology, Poznań University of Medical Sciences, Przybyszewskiego 49 St., 60-355 Poznań, PolandDepartment of Otolaryngology and Laryngological Oncology, Poznań University of Medical Sciences, Przybyszewskiego 49 St., 60-355 Poznań, PolandDepartment of Otolaryngology and Laryngological Oncology, Poznań University of Medical Sciences, Przybyszewskiego 49 St., 60-355 Poznań, PolandDepartment of Immunobiology, Poznań University of Medical Sciences, Rokietnicka 8 St., 60-812 Poznań, PolandDepartment of Immunobiology, Poznań University of Medical Sciences, Rokietnicka 8 St., 60-812 Poznań, PolandDepartment of Otolaryngology and Laryngological Oncology, Poznań University of Medical Sciences, Przybyszewskiego 49 St., 60-355 Poznań, PolandChronic rhinosinusitis (CRS) is a common inflammatory disease of the paranasal sinuses with a yet unknown etiology. As studies continue to elucidate the disease’s heterogeneity inflammatory profile and presentation, there is a growing interest in the influence of the nasal microbiome on disease pathogenesis and chronicity. The sinus microbiota appear dominated by the <i>Staphylococcus</i> and <i>Corynebacterium</i> genera; known upper airway pathogens, such as <i>Haemophilus influenza</i>, are present in the upper airways of healthy individuals, though at relatively lower abundances than in CRS patients. Viral culprits may induce an unhindered local immune response that contributes to the recurrence and chronicity of inverted papillomas—benign mucosal lesions with the propensity for local destruction and malignant transformation that can be found in patients with a history of nasal infection. The persistence of inverted papillomas warrants investigation into their pathogenesis and how they may contribute to a nasal landscape promoting the chronicity of CRS. Further investigation is needed to uncover the interplay between resident microbiota and viral, fungal, and immunological influence. Discerning between ‘healthy’ and ‘diseased’ sinonasal microbiomes and ‘keystone’ species could shed light on CRS etiology and provide the opportunity for CRS treatment tailored to an individual’s microbiome. This review aims to explore the interrelation of microbial residents in the pathogenesis and chronicity of the diseased sinonasal environment.https://www.mdpi.com/2076-0817/14/1/14chronic rhinosinusitis (CRS)nasal polypsmicrobiomedysbiosisinverted papillomaupper airway |
| spellingShingle | Mateusz de Mezer Nina Chalama Cheyanna Bratt Melanie Kiebalo Natalia Dolata Jan Rogaliński Małgorzata Leszczyńska Changes in the Microbiome During Chronic Rhinosinusitis Pathogens chronic rhinosinusitis (CRS) nasal polyps microbiome dysbiosis inverted papilloma upper airway |
| title | Changes in the Microbiome During Chronic Rhinosinusitis |
| title_full | Changes in the Microbiome During Chronic Rhinosinusitis |
| title_fullStr | Changes in the Microbiome During Chronic Rhinosinusitis |
| title_full_unstemmed | Changes in the Microbiome During Chronic Rhinosinusitis |
| title_short | Changes in the Microbiome During Chronic Rhinosinusitis |
| title_sort | changes in the microbiome during chronic rhinosinusitis |
| topic | chronic rhinosinusitis (CRS) nasal polyps microbiome dysbiosis inverted papilloma upper airway |
| url | https://www.mdpi.com/2076-0817/14/1/14 |
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