Cryoablation for the treatment of chronic rhinitis: a systematic review
Abstract Background ClariFix is a novel intranasal cryotherapy device developed for clinic-based cryosurgical ablation of the posterior nasal nerves region. As a relatively new technology, there is a paucity of studies within the literature assessing the efficacy and safety profile of ClariFix for c...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-04-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
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| Online Access: | https://doi.org/10.1186/s40463-023-00645-6 |
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| _version_ | 1832565289353478144 |
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| author | Veeral Desai Gianluca Sampieri Amirpouyan Namavarian John M. Lee |
| author_facet | Veeral Desai Gianluca Sampieri Amirpouyan Namavarian John M. Lee |
| author_sort | Veeral Desai |
| collection | DOAJ |
| description | Abstract Background ClariFix is a novel intranasal cryotherapy device developed for clinic-based cryosurgical ablation of the posterior nasal nerves region. As a relatively new technology, there is a paucity of studies within the literature assessing the efficacy and safety profile of ClariFix for chronic rhinitis. Methods A systematic review was completed in accordance with PRISMA guidelines. Databases searched included: Ovid Medline, Ovid EMBASE, Pubmed, Cochrane and Web of Science. Inclusion criteria consisted of studies investigating the use of ClariFix in chronic rhinitis (i.e., allergic and non-allergic rhinitis) in patients of all ages. Results The initial search identified 1110 studies. Final analysis consisted of 8 articles, evaluating a total of 472 patients. The data showed a significant reduction in scores post-treatment across all studies based on validated outcome measures. In all studies, at all time intervals, there was a significant improvement in outcome scores from baseline. Minor adverse effects included post-procedural pain and discomfort, headache and palate numbness. No major adverse events were identified. Conclusion ClariFix is a novel intranasal cryotherapy device that was introduced in Canada in 2021. This is the first systematic review evaluating its efficacy and safety profile. Across all studies, there was a significant reduction in validated outcome scores at multiple time intervals. Further, the treatment is safe with only minor adverse effects reported by patients. Overall, the consensus from this study highlights an apparent benefit in using this intervention for chronic rhinitis that is refractory to medical management. |
| format | Article |
| id | doaj-art-258ffa5a8c2b437b8210d0d00805ffd9 |
| institution | Kabale University |
| issn | 1916-0216 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj-art-258ffa5a8c2b437b8210d0d00805ffd92025-02-03T01:08:31ZengSAGE PublishingJournal of Otolaryngology - Head and Neck Surgery1916-02162023-04-015211910.1186/s40463-023-00645-6Cryoablation for the treatment of chronic rhinitis: a systematic reviewVeeral Desai0Gianluca Sampieri1Amirpouyan Namavarian2John M. Lee3Faculty of Medicine, Queen’s UniversityDepartment of Otolaryngology – Head and Neck Surgery, University of TorontoDepartment of Otolaryngology – Head and Neck Surgery, University of TorontoDepartment of Otolaryngology – Head and Neck Surgery, University of TorontoAbstract Background ClariFix is a novel intranasal cryotherapy device developed for clinic-based cryosurgical ablation of the posterior nasal nerves region. As a relatively new technology, there is a paucity of studies within the literature assessing the efficacy and safety profile of ClariFix for chronic rhinitis. Methods A systematic review was completed in accordance with PRISMA guidelines. Databases searched included: Ovid Medline, Ovid EMBASE, Pubmed, Cochrane and Web of Science. Inclusion criteria consisted of studies investigating the use of ClariFix in chronic rhinitis (i.e., allergic and non-allergic rhinitis) in patients of all ages. Results The initial search identified 1110 studies. Final analysis consisted of 8 articles, evaluating a total of 472 patients. The data showed a significant reduction in scores post-treatment across all studies based on validated outcome measures. In all studies, at all time intervals, there was a significant improvement in outcome scores from baseline. Minor adverse effects included post-procedural pain and discomfort, headache and palate numbness. No major adverse events were identified. Conclusion ClariFix is a novel intranasal cryotherapy device that was introduced in Canada in 2021. This is the first systematic review evaluating its efficacy and safety profile. Across all studies, there was a significant reduction in validated outcome scores at multiple time intervals. Further, the treatment is safe with only minor adverse effects reported by patients. Overall, the consensus from this study highlights an apparent benefit in using this intervention for chronic rhinitis that is refractory to medical management.https://doi.org/10.1186/s40463-023-00645-6RhinitisEndoscopic sinus surgeryChronic disease |
| spellingShingle | Veeral Desai Gianluca Sampieri Amirpouyan Namavarian John M. Lee Cryoablation for the treatment of chronic rhinitis: a systematic review Journal of Otolaryngology - Head and Neck Surgery Rhinitis Endoscopic sinus surgery Chronic disease |
| title | Cryoablation for the treatment of chronic rhinitis: a systematic review |
| title_full | Cryoablation for the treatment of chronic rhinitis: a systematic review |
| title_fullStr | Cryoablation for the treatment of chronic rhinitis: a systematic review |
| title_full_unstemmed | Cryoablation for the treatment of chronic rhinitis: a systematic review |
| title_short | Cryoablation for the treatment of chronic rhinitis: a systematic review |
| title_sort | cryoablation for the treatment of chronic rhinitis a systematic review |
| topic | Rhinitis Endoscopic sinus surgery Chronic disease |
| url | https://doi.org/10.1186/s40463-023-00645-6 |
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