Eosinophilic Esophagitis in Two Patients with Systemic Sclerosis
The gastrointestinal tract (GIT) is the most common extracutaneous organ system damaged in systemic sclerosis (SSc) and is the presenting feature in 10% of patients. The esophagus as the portion of the GIT is the most commonly affected and there is an association of gastroesophageal reflux (GER) wit...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2016/6410421 |
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| _version_ | 1832554410454024192 |
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| author | Tracy M. Frech Kathleen Boynton Erinn Downs-Kelly Bryan Jones John D. Kriesel Kathryn Peterson |
| author_facet | Tracy M. Frech Kathleen Boynton Erinn Downs-Kelly Bryan Jones John D. Kriesel Kathryn Peterson |
| author_sort | Tracy M. Frech |
| collection | DOAJ |
| description | The gastrointestinal tract (GIT) is the most common extracutaneous organ system damaged in systemic sclerosis (SSc) and is the presenting feature in 10% of patients. The esophagus as the portion of the GIT is the most commonly affected and there is an association of gastroesophageal reflux (GER) with SSc interstitial lung disease (ILD). Thus, an aggressive treatment for GER is recommended in all SSc patients with ILD; however, it is recognized that a long-term benefit to this treatment is needed to understand its impact. In this case report we discuss the presence of eosinophilic esophagitis (EoE) in two SSc patients and discuss the role for early EGD in SSc patients with moderate-severe GER symptoms for tissue study. Assessment of esophageal biopsy specimens for the presence of eosinophils and possibly ANA can help elucidate disease pathogenesis and direct therapy, as the presence of EoE in SSc has important management considerations, particularly with regards to dietary modification strategies. |
| format | Article |
| id | doaj-art-256752393ea44bf4b8efb1618f9f0713 |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-256752393ea44bf4b8efb1618f9f07132025-02-03T05:51:33ZengWileyCase Reports in Rheumatology2090-68892090-68972016-01-01201610.1155/2016/64104216410421Eosinophilic Esophagitis in Two Patients with Systemic SclerosisTracy M. Frech0Kathleen Boynton1Erinn Downs-Kelly2Bryan Jones3John D. Kriesel4Kathryn Peterson5Division of Rheumatology, Department of Internal Medicine, University of Utah School of Medicine, 4B200 30 N. 1900 E., Salt Lake City, UT 84132, USADivision of Gastroenterology, Department of Internal Medicine, University of Utah, 50 N Medical Drive, Salt Lake City, UT 84132, USADepartment of Anatomic Pathology, University of Utah, 50 N Medical Drive, Salt Lake City, UT 84132, USADepartment of Ophthalmology, University of Utah, 50 N Medical Drive, Salt Lake City, UT 84132, USADivision of Infectious Diseases, Department of Internal Medicine, University of Utah, 50 N Medical Drive, Salt Lake City, UT 84132, USADivision of Gastroenterology, Department of Internal Medicine, University of Utah, 50 N Medical Drive, Salt Lake City, UT 84132, USAThe gastrointestinal tract (GIT) is the most common extracutaneous organ system damaged in systemic sclerosis (SSc) and is the presenting feature in 10% of patients. The esophagus as the portion of the GIT is the most commonly affected and there is an association of gastroesophageal reflux (GER) with SSc interstitial lung disease (ILD). Thus, an aggressive treatment for GER is recommended in all SSc patients with ILD; however, it is recognized that a long-term benefit to this treatment is needed to understand its impact. In this case report we discuss the presence of eosinophilic esophagitis (EoE) in two SSc patients and discuss the role for early EGD in SSc patients with moderate-severe GER symptoms for tissue study. Assessment of esophageal biopsy specimens for the presence of eosinophils and possibly ANA can help elucidate disease pathogenesis and direct therapy, as the presence of EoE in SSc has important management considerations, particularly with regards to dietary modification strategies.http://dx.doi.org/10.1155/2016/6410421 |
| spellingShingle | Tracy M. Frech Kathleen Boynton Erinn Downs-Kelly Bryan Jones John D. Kriesel Kathryn Peterson Eosinophilic Esophagitis in Two Patients with Systemic Sclerosis Case Reports in Rheumatology |
| title | Eosinophilic Esophagitis in Two Patients with Systemic Sclerosis |
| title_full | Eosinophilic Esophagitis in Two Patients with Systemic Sclerosis |
| title_fullStr | Eosinophilic Esophagitis in Two Patients with Systemic Sclerosis |
| title_full_unstemmed | Eosinophilic Esophagitis in Two Patients with Systemic Sclerosis |
| title_short | Eosinophilic Esophagitis in Two Patients with Systemic Sclerosis |
| title_sort | eosinophilic esophagitis in two patients with systemic sclerosis |
| url | http://dx.doi.org/10.1155/2016/6410421 |
| work_keys_str_mv | AT tracymfrech eosinophilicesophagitisintwopatientswithsystemicsclerosis AT kathleenboynton eosinophilicesophagitisintwopatientswithsystemicsclerosis AT erinndownskelly eosinophilicesophagitisintwopatientswithsystemicsclerosis AT bryanjones eosinophilicesophagitisintwopatientswithsystemicsclerosis AT johndkriesel eosinophilicesophagitisintwopatientswithsystemicsclerosis AT kathrynpeterson eosinophilicesophagitisintwopatientswithsystemicsclerosis |