The Spatial Transcriptional Activity of Hepatic TCF7L2 Regulates Zonated Metabolic Pathways that Contribute to Liver Fibrosis

The Spatial Transcriptional Activity of Hepatic TCF7L2 Regulates Zonated Metabolic Pathways that Contribute to Liver Fibrosis

Abstract The molecular mechanisms regulating the zonal distribution of metabolism in liver are incompletely understood. Here we use single nuclei genomics techniques to examine the spatial transcriptional function of transcription factor 7-like 2 (TCF7L2) in mouse liver, and determine the consequenc...

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Main Authors: Iriscilla Ayala, Skanda K. Hebbale, Juho Mononen, Madelaine C. Brearley-Sholto, Christopher E. Shannon, Ivan Valdez, Marcel Fourcaudot, Terry M. Bakewell, Anna Zagorska, Giovanna Romero, Mara Asmis, Fatima A. Musa, Jonah T. Sily, Annie A. Smelter, Edgar A. Hinostroza, Leandro C. Freitas Lima, Thomas Q. de Aguiar Vallim, Sami Heikkinen, Luke Norton
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58714-5
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https://doi.org/10.1038/s41467-025-58714-5

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