REGγ regulates antiviral response by activating TBK1-IFNβ signaling through degradation of PPP2CB

REGγ regulates antiviral response by activating TBK1-IFNβ signaling through degradation of PPP2CB

Abstract Although significant progressions in antiviral studies of IFNβ have been demonstrated, the role of the proteasome in modulating cross-talk between TBK1-IFNβ signaling and viral replication during viral infection is not fully elucidated. Here, we discover that deficiency of REGγ, a proteasom...

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Bibliographic Details
Main Authors: Yi Li, Pei Wang, Jiamin Ma, Qing Tu, Yuan Yuan, Ying Chen, Lin Wang, Yuwei Chen, Feng Chen, Suvi Biesinger, Henry J. Li, Jinbao Li, Liangfang Yao
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Cellular and Molecular Life Sciences
Subjects:
REGγ
PPP2CB
TBK1
IFNβ
Viral infection
Online Access:https://doi.org/10.1007/s00018-025-05816-4
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https://doi.org/10.1007/s00018-025-05816-4

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