Accurate detection of pathologic α-synuclein in CSF, skin, olfactory mucosa, and urine with a uniform seeding amplification assay

Accurate detection of pathologic α-synuclein in CSF, skin, olfactory mucosa, and urine with a uniform seeding amplification assay

Abstract Currently, early diagnosis of dementia with Lewy bodies (DLB) is based on clinical criteria, which is challenging due to overlapping symptoms with other neurodegenerative diseases. Seeding amplification assays, detecting minute amounts of disease causing α-synuclein (αSynD), are emerging as...

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Main Authors: Remarh Bsoul, Oskar H. McWilliam, Gunhild Waldemar, Steen G. Hasselbalch, Anja H. Simonsen, Christian von Buchwald, Magne Bech, Clara H. Pinborg, Christian K. Pedersen, Sara O. Baungaard, José Lombardía, Patrick Ejlerskov, Matilde Bongianni, Erika Bronzato, Gianluigi Zanusso, Kristian S. Frederiksen, Eva L. Lund, Aušrinė Areškevičiūtė
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Acta Neuropathologica Communications
Subjects:
Real-time quaking-induced conversion
RT-QuIC
Amplification assay
Neurodegenerative
Lewy body
Skin
Online Access:https://doi.org/10.1186/s40478-025-02034-8
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https://doi.org/10.1186/s40478-025-02034-8

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