Nanoscale engineered exosomes for dual delivery of Sirtuin3 and insulin to ignite mitochondrial recovery in myocardial ischemia-reperfusion

Nanoscale engineered exosomes for dual delivery of Sirtuin3 and insulin to ignite mitochondrial recovery in myocardial ischemia-reperfusion

Abstract Background Acute myocardial infarction remains a leading cause of mortality, with ischemia-reperfusion (I/R) injury causing severe myocardial damage through mitochondrial dysfunction. While mesenchymal stem cell-derived exosomes (MSC-Exo) show therapeutic potential, their limited targeting...

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Main Authors: Jiaxin Yang, Xinyi Yun, Weihan Zheng, Huihui Zhang, Zi Yan, Youyu Chen, Wanting Xue, Siqi Mi, Ziyue Li, Hanxiao Sun, Guozhi Xiao, Zhenning Dai, Shiyu Li, Wenhua Huang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Nanobiotechnology
Online Access:https://doi.org/10.1186/s12951-025-03474-z
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https://doi.org/10.1186/s12951-025-03474-z

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