Sodium-glucose cotransporter-2 inhibitors increase urinary tract infections?—a cross sectional analysis of a nationwide Japanese claims database
Sodium-glucose cotransporter-2 (SGLT2) inhibitors are a novel class of antidiabetic drugs. Guidelines for the proper use of SGLT2 inhibitors recommend caution regarding urinary tract infections (UTIs). However, little evidence has been reported on the relationship between SGLT2 inhibitors and UTIs i...
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| Format: | Article |
| Language: | English |
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The Japan Endocrine Society
2023-11-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/70/11/70_EJ23-0317/_html/-char/en |
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| author | Go Anan Daisuke Kikuchi Kenji Omae Takuo Hirose Kouji Okada Takefumi Mori |
| author_facet | Go Anan Daisuke Kikuchi Kenji Omae Takuo Hirose Kouji Okada Takefumi Mori |
| author_sort | Go Anan |
| collection | DOAJ |
| description | Sodium-glucose cotransporter-2 (SGLT2) inhibitors are a novel class of antidiabetic drugs. Guidelines for the proper use of SGLT2 inhibitors recommend caution regarding urinary tract infections (UTIs). However, little evidence has been reported on the relationship between SGLT2 inhibitors and UTIs in large epidemiological studies. We investigated (1) the relationship between diabetes mellitus (DM) and UTIs and (2) the relationship between SGLT2 inhibitor prescriptions and the likelihood of developing UTIs in patients with DM, using a nationwide Japanese health insurance claims database by MDV analyzer®. We found that the incidence of UTIs was significantly higher among patients with DM than among those without DM (odds ratio (OR), 1.71; 95% confidence interval (CI), 1.69–1.72, for male; OR, 1.90; 95% CI, 1.89–1.92 for female). In contrast, in male patients with DM, the prescription of SGLT2 inhibitors was negatively associated with the likelihood of developing UTIs (OR, 0.74; 95% CI, 0.72–0.75). Among female patients with DM, there was no significant difference in the incidence of UTIs with or without an SGLT2 inhibitor prescription (OR, 0.99; 95% CI, 0.96–1.01). Subgroup analyses by age confirmed similar relationships between SGLT2 inhibitor prescriptions and UTIs, except for female patients aged ≤39 years, in whom SGLT2 inhibitor prescription was negatively associated with the likelihood of developing UTIs. In conclusion, our analysis of a nationwide claims database found no evidence that SGLT2 inhibitors increase UTIs in Japanese patients with DM, regardless of sex or age. |
| format | Article |
| id | doaj-art-24d8b2e3a13f4e5c925d213fc591d92c |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-24d8b2e3a13f4e5c925d213fc591d92c2025-01-22T06:23:19ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402023-11-0170111103110710.1507/endocrj.EJ23-0317endocrjSodium-glucose cotransporter-2 inhibitors increase urinary tract infections?—a cross sectional analysis of a nationwide Japanese claims databaseGo Anan0Daisuke Kikuchi1Kenji Omae2Takuo Hirose3Kouji Okada4Takefumi Mori5Department of Urology, Yotsuya Medical Cube, Tokyo 102-0084, JapanDepartment of Pharmacy, Tohoku Medical and Pharmaceutical University Hospital, Sendai 983-8512, JapanDepartment of Innovative Research and Education for Clinicians and Trainees (DiRECT), Fukushima Medical University Hospital, Fukushima 960-1295, JapanDivision of Nephrology and Endocrinology, Tohoku Medical and Pharmaceutical University, Sendai 983-8536, JapanDepartment of Pharmacy, Tohoku Medical and Pharmaceutical University Hospital, Sendai 983-8512, JapanDivision of Nephrology and Endocrinology, Tohoku Medical and Pharmaceutical University, Sendai 983-8536, JapanSodium-glucose cotransporter-2 (SGLT2) inhibitors are a novel class of antidiabetic drugs. Guidelines for the proper use of SGLT2 inhibitors recommend caution regarding urinary tract infections (UTIs). However, little evidence has been reported on the relationship between SGLT2 inhibitors and UTIs in large epidemiological studies. We investigated (1) the relationship between diabetes mellitus (DM) and UTIs and (2) the relationship between SGLT2 inhibitor prescriptions and the likelihood of developing UTIs in patients with DM, using a nationwide Japanese health insurance claims database by MDV analyzer®. We found that the incidence of UTIs was significantly higher among patients with DM than among those without DM (odds ratio (OR), 1.71; 95% confidence interval (CI), 1.69–1.72, for male; OR, 1.90; 95% CI, 1.89–1.92 for female). In contrast, in male patients with DM, the prescription of SGLT2 inhibitors was negatively associated with the likelihood of developing UTIs (OR, 0.74; 95% CI, 0.72–0.75). Among female patients with DM, there was no significant difference in the incidence of UTIs with or without an SGLT2 inhibitor prescription (OR, 0.99; 95% CI, 0.96–1.01). Subgroup analyses by age confirmed similar relationships between SGLT2 inhibitor prescriptions and UTIs, except for female patients aged ≤39 years, in whom SGLT2 inhibitor prescription was negatively associated with the likelihood of developing UTIs. In conclusion, our analysis of a nationwide claims database found no evidence that SGLT2 inhibitors increase UTIs in Japanese patients with DM, regardless of sex or age.https://www.jstage.jst.go.jp/article/endocrj/70/11/70_EJ23-0317/_html/-char/ensodium-glucose cotransporter-2 inhibitorurinary tract infectionepidemiological studydiabetes mellitus |
| spellingShingle | Go Anan Daisuke Kikuchi Kenji Omae Takuo Hirose Kouji Okada Takefumi Mori Sodium-glucose cotransporter-2 inhibitors increase urinary tract infections?—a cross sectional analysis of a nationwide Japanese claims database Endocrine Journal sodium-glucose cotransporter-2 inhibitor urinary tract infection epidemiological study diabetes mellitus |
| title | Sodium-glucose cotransporter-2 inhibitors increase urinary tract infections?—a cross sectional analysis of a nationwide Japanese claims database |
| title_full | Sodium-glucose cotransporter-2 inhibitors increase urinary tract infections?—a cross sectional analysis of a nationwide Japanese claims database |
| title_fullStr | Sodium-glucose cotransporter-2 inhibitors increase urinary tract infections?—a cross sectional analysis of a nationwide Japanese claims database |
| title_full_unstemmed | Sodium-glucose cotransporter-2 inhibitors increase urinary tract infections?—a cross sectional analysis of a nationwide Japanese claims database |
| title_short | Sodium-glucose cotransporter-2 inhibitors increase urinary tract infections?—a cross sectional analysis of a nationwide Japanese claims database |
| title_sort | sodium glucose cotransporter 2 inhibitors increase urinary tract infections a cross sectional analysis of a nationwide japanese claims database |
| topic | sodium-glucose cotransporter-2 inhibitor urinary tract infection epidemiological study diabetes mellitus |
| url | https://www.jstage.jst.go.jp/article/endocrj/70/11/70_EJ23-0317/_html/-char/en |
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