Isatin Bis-Imidathiazole Hybrids Identified as FtsZ Inhibitors with On-Target Activity Against <i>Staphylococcus aureus</i>

Isatin Bis-Imidathiazole Hybrids Identified as FtsZ Inhibitors with On-Target Activity Against <i>Staphylococcus aureus</i>

In the present study, a series of isatin bis-imidathiazole hybrids was designed and synthesized to develop a new class of heterocyclic compounds with improved antimicrobial activity against pathogens responsible for hospital- and community-acquired infections. A remarkable inhibitory activity agains...

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Bibliographic Details
Main Authors: Rita Morigi, Daniele Esposito, Matteo Calvaresi, Tainah Dorina Marforio, Giovanna Angela Gentilomi, Francesca Bonvicini, Alessandra Locatelli
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Antibiotics
Subjects:
isatin bis-imidathiazole hybrids
antibacterial activity
MRSA
FtsZ inhibitors
molecular dynamics simulations
Online Access:https://www.mdpi.com/2079-6382/13/10/992
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