5-methylcytosine regulated CCNL2 promotes tumorigenesis and cisplatin resistance of ovarian cancer with therapeutic implications

5-methylcytosine regulated CCNL2 promotes tumorigenesis and cisplatin resistance of ovarian cancer with therapeutic implications

Abstract Backgroud Ovarian cancer (OC) is the most lethal gynecological tumor, primarily due to resistance to chemotherapy. Cyclin L2 (CCNL2) is a novel member of the cyclin family and mainly localized in nucleus. It regulates transcription and alternative splicing by interacting with cyclin-depende...

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Bibliographic Details
Main Authors: Kai Zhang, Guiyun Cheng, Wenwen Jiang, Beihua Kong, Shu Yao, Xihan Liu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Ovarian Research
Subjects:
Ovarian cancer
Chemoresistance
CCNL2
5-methylcytosine
Online Access:https://doi.org/10.1186/s13048-025-01753-9
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