Dysregulated ATX-LPA and YAP/TAZ signaling in dystrophic Sgcd −/− mice with early fibrosis and inflammation

Dysregulated ATX-LPA and YAP/TAZ signaling in dystrophic Sgcd −/− mice with early fibrosis and inflammation

Abstract Background Sarcoglycanopathies are muscle dystrophies caused by mutations in the genes encoding sarcoglycans (α, β, γ, and δ) that can destabilize the dystrophin-associated glycoprotein complex at the sarcolemma, leaving muscle fibers vulnerable to damage after contraction, followed by infl...

Full description

Saved in:
Bibliographic Details
Main Authors: Cristian Gutiérrez-Rojas, Adriana Córdova-Casanova, Jennifer Faundez-Contreras, Meilyn Cruz-Soca, Felipe S. Gallardo, Alexia Bock-Pereda, Juan Carlos Casar, Elisabeth R. Barton, Enrique Brandan
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Skeletal Muscle
Subjects:
δ Sarcoglycanopathy
Autotaxin
Lysophosphatidic acid
Fibrosis
Inflammation
Muscle regeneration
Online Access:https://doi.org/10.1186/s13395-025-00375-5
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13395-025-00375-5

Similar Items