Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants
Background. Renal damage caused by drug toxicity is becoming increasingly common in the clinic. Preventing and treating kidney damage caused by drug toxicity are essential to maintain patient health and reduce the social and economic burden. In this study, we performed a meta-analysis to assess the...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2020/8819757 |
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| author | Shujun Lin Wenshan Lin Chunling Liao Tianbiao Zhou |
| author_facet | Shujun Lin Wenshan Lin Chunling Liao Tianbiao Zhou |
| author_sort | Shujun Lin |
| collection | DOAJ |
| description | Background. Renal damage caused by drug toxicity is becoming increasingly common in the clinic. Preventing and treating kidney damage caused by drug toxicity are essential to maintain patient health and reduce the social and economic burden. In this study, we performed a meta-analysis to assess the nephroprotective effect of mesenchymal stem cells (MSCs) in the treatment of kidney disease induced by toxicants. Methods. The Cochrane Library, Embase, ISI Web of Science, and PubMed databases were searched up to December 31, 2019, to identify studies and extract data to assess the efficacy of MSCs treatment of kidney disease induced by toxicants using Cochrane Review Manager Version 5.3. A total of 27 studies were eligible and selected for this meta-analysis. Results. The results showed that a difference in serum creatinine levels between the MSC treatment group and control group was observed for 2, 4, 5, 6-8, 10-15, 28-30, and ≥42 days (2 days: WMD=−0.88, 95% CI: -1.34, -0.42, P=0.0002; 4 days: WMD=−0.74, 95% CI: -0.95, -0.54, P<0.00001; 5 days: WMD=−0.46, 95% CI: -0.67, -0.25, P<0.0001; 6-8 days: WMD=−0.55, 95% CI: -0.84, -0.26, P=0.0002; 10-15 days: WMD=−0.37, 95% CI: -0.53, -0.20, P<0.0001; 28-30 days: WMD=−0.53, 95% CI: -1.04, -0.02, P=0.04; ≥42 days: WMD=−0.22, 95% CI: -0.39, -0.06, P=0.007). Furthermore, a difference in blood urea nitrogen levels between the MSC treatment group and control group was observed for 2-3, 4-5, 6-8, and ≥28 days. The results also indicate that MSC treatment alleviated inflammatory cells, necrotic tubules, regenerative tubules, and renal interstitial fibrosis in kidney disease induced by toxicants. Conclusion. MSCs may be a promising therapeutic agent for kidney disease induced by toxicants. |
| format | Article |
| id | doaj-art-24ae70cbf9d24b88a242d4e9b7e1e507 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-24ae70cbf9d24b88a242d4e9b7e1e5072025-02-03T00:58:53ZengWileyStem Cells International1687-966X1687-96782020-01-01202010.1155/2020/88197578819757Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by ToxicantsShujun Lin0Wenshan Lin1Chunling Liao2Tianbiao Zhou3Department of Nephrology, The Second Affiliated Hospital, Shantou University Medical College, 515041 Shantou, ChinaDepartment of Nephrology, The Second Affiliated Hospital, Shantou University Medical College, 515041 Shantou, ChinaDepartment of Nephrology, The Second Affiliated Hospital, Shantou University Medical College, 515041 Shantou, ChinaDepartment of Nephrology, The Second Affiliated Hospital, Shantou University Medical College, 515041 Shantou, ChinaBackground. Renal damage caused by drug toxicity is becoming increasingly common in the clinic. Preventing and treating kidney damage caused by drug toxicity are essential to maintain patient health and reduce the social and economic burden. In this study, we performed a meta-analysis to assess the nephroprotective effect of mesenchymal stem cells (MSCs) in the treatment of kidney disease induced by toxicants. Methods. The Cochrane Library, Embase, ISI Web of Science, and PubMed databases were searched up to December 31, 2019, to identify studies and extract data to assess the efficacy of MSCs treatment of kidney disease induced by toxicants using Cochrane Review Manager Version 5.3. A total of 27 studies were eligible and selected for this meta-analysis. Results. The results showed that a difference in serum creatinine levels between the MSC treatment group and control group was observed for 2, 4, 5, 6-8, 10-15, 28-30, and ≥42 days (2 days: WMD=−0.88, 95% CI: -1.34, -0.42, P=0.0002; 4 days: WMD=−0.74, 95% CI: -0.95, -0.54, P<0.00001; 5 days: WMD=−0.46, 95% CI: -0.67, -0.25, P<0.0001; 6-8 days: WMD=−0.55, 95% CI: -0.84, -0.26, P=0.0002; 10-15 days: WMD=−0.37, 95% CI: -0.53, -0.20, P<0.0001; 28-30 days: WMD=−0.53, 95% CI: -1.04, -0.02, P=0.04; ≥42 days: WMD=−0.22, 95% CI: -0.39, -0.06, P=0.007). Furthermore, a difference in blood urea nitrogen levels between the MSC treatment group and control group was observed for 2-3, 4-5, 6-8, and ≥28 days. The results also indicate that MSC treatment alleviated inflammatory cells, necrotic tubules, regenerative tubules, and renal interstitial fibrosis in kidney disease induced by toxicants. Conclusion. MSCs may be a promising therapeutic agent for kidney disease induced by toxicants.http://dx.doi.org/10.1155/2020/8819757 |
| spellingShingle | Shujun Lin Wenshan Lin Chunling Liao Tianbiao Zhou Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants Stem Cells International |
| title | Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants |
| title_full | Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants |
| title_fullStr | Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants |
| title_full_unstemmed | Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants |
| title_short | Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants |
| title_sort | nephroprotective effect of mesenchymal stem cell based therapy of kidney disease induced by toxicants |
| url | http://dx.doi.org/10.1155/2020/8819757 |
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