IL-7 promotes integrated glucose and amino acid sensing during homeostatic CD4+ T cell proliferation

IL-7 promotes integrated glucose and amino acid sensing during homeostatic CD4+ T cell proliferation

Summary: Interleukin (IL)-7 promotes T cell expansion during lymphopenia. We studied the metabolic basis in CD4+ T cells, observing increased glucose usage for nucleotide synthesis and oxidation in the tricarboxylic acid (TCA) cycle. Unlike other TCA metabolites, glucose-derived citrate does not acc...

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Bibliographic Details
Main Authors: Seema Bachoo, Nancy Gudgeon, Rebecca Mann, Victoria Stavrou, Emma L. Bishop, Audrey Kelly, Alejandro Huerta Uribe, Jordan Loeliger, Corina Frick, Oliver D.K. Maddocks, Paul Lavender, Christoph Hess, Sarah Dimeloe
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cell Reports
Subjects:
Immunology
Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472401550X
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http://www.sciencedirect.com/science/article/pii/S221112472401550X

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