The crucial role of neutrophil extracellular traps and IL-17 signaling in indomethacin-induced gastric injury in mice

The crucial role of neutrophil extracellular traps and IL-17 signaling in indomethacin-induced gastric injury in mice

Abstract The homeostasis of gastric mucosa is extremely delicate. Neutrophils, the most abundant immune cells in human circulation, are regarded crutial in the regulation of gastric mucosal immune response. Non-steroidal anti-inflammatory drugs (NSAIDs) induced gastric injury is the second major rea...

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Main Authors: Yujun Hou, Wen Wang, Jiangnan Ye, Luqiang Sun, Siyuan Zhou, Qianhua Zheng, Yunzhou Shi, Ying Chen, Junpeng Yao, Lu Wang, Xiangyun Yan, Renhong Wan, Shuai Chen, Ying Li
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Gastric injury
Indomethacin
Neutrophil extracellular traps (NETs)
Gastric epithelial cells (GECs)
IL-17
Online Access:https://doi.org/10.1038/s41598-025-95880-4
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https://doi.org/10.1038/s41598-025-95880-4

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