Tripterygium Glycosides Tablet Ameliorates Renal Tubulointerstitial Fibrosis via the Toll-Like Receptor 4/Nuclear Factor Kappa B Signaling Pathway in High-Fat Diet Fed and Streptozotocin-Induced Diabetic Rats

Tripterygium Glycosides Tablet Ameliorates Renal Tubulointerstitial Fibrosis via the Toll-Like Receptor 4/Nuclear Factor Kappa B Signaling Pathway in High-Fat Diet Fed and Streptozotocin-Induced Diabetic Rats

Tripterygium glycosides tablet (TGT) is a Chinese traditional medicine that has been shown to protect podocytes from injury and reduce the proteinuria. The aim of this study was to assess the effect of TGT on renal tubulointerstitial fibrosis and its potential mechanism in high-fat diet fed and STZ-...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ze-jun Ma, Xiao-na Zhang, Li Li, Wei Yang, Shan-shan Wang, Xin Guo, Pei Sun, Li-ming Chen
Format:	Article
Language:	English
Published:	Wiley 2015-01-01
Series:	Journal of Diabetes Research
Online Access:	http://dx.doi.org/10.1155/2015/390428
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Valsartan in Combination with Tripterygium Glycosides Protects against Chronic Nephritis via the Toll-Like Receptor 4 Pathway
by: Jiabao Dong, et al.
Published: (2022-01-01)

Efficacy and Safety of Tripterygium Wilfordii Glycoside Tablets Combined with Acitretin Capsules in the Treatment of Moderate to Severe Plaque Psoriasis: A Randomized Controlled Trial
by: Qinghui Fu, et al.
Published: (2022-01-01)

Efficacy of Chlorogenic Acid in Treating Tripterygium Glycoside-Induced Asthenozoospermia in Rats and Its Possible Mechanisms
by: Long Chen, et al.
Published: (2025-01-01)

Scutellarin Attenuates Hypertension-Induced Expression of Brain Toll-Like Receptor 4/Nuclear Factor Kappa B
by: Xingyong Chen, et al.
Published: (2013-01-01)

Extract of Sesbania grandiflora Ameliorates Hyperglycemia in High Fat Diet-Streptozotocin Induced Experimental Diabetes Mellitus
by: Ghanshyam Panigrahi, et al.
Published: (2016-01-01)

Inhibitors of nuclear factor kappa B cause apoptosis in cultured macrophages
by: E. E. Mannick, et al.
Published: (1997-01-01)

Partial Replacement with Menhaden Oil Improves Peripheral Neuropathy in High-Fat-Fed Low-Dose Streptozotocin Type 2 Diabetic Rat
by: Lawrence J. Coppey, et al.
Published: (2012-01-01)

Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-Fed/Low-Dose Streptozotocin-Treated Sprague Dawley Rats
by: Eric P. Davidson, et al.
Published: (2018-01-01)

Study on association of nuclear factor kappa B gene polymorphism with bacterial load in pulmonary tuberculosis
by: Pallavi Baliarsingh, et al.
Published: (2023-12-01)

NET-Related Gene as Potential Diagnostic Biomarkers for Diabetic Tubulointerstitial Injury
by: Yufeng Liang, et al.
Published: (2024-01-01)

Moringa oleifera Lam. leaf extract mitigates carbon tetrachloride-mediated hepatic inflammation and apoptosis via targeting oxidative stress and toll-like receptor 4/nuclear factor kappa B pathway in mice
by: Samah M. Fathy, et al.
Published: (2021-05-01)

RETRACTED ARTICLE: P16INK4a Deletion Ameliorated Renal Tubulointerstitial Injury in a Stress-induced Premature Senescence Model of Bmi-1 Deficiency
by: Jianliang Jin, et al.
Published: (2017-08-01)

Retraction Note: P16 INK4a deletion ameliorated renal tubulointerstitial injury in a stress-induced premature senescence model of Bmi-1 deficiency
by: Jianliang Jin, et al.
Published: (2025-01-01)

Growth, fat metabolism and hepatic health in largemouth bass fed varying fat-level diets
by: Digen Qin, et al.
Published: (2025-03-01)

Escin Chemosensitizes Human Pancreatic Cancer Cells and Inhibits the Nuclear Factor-kappaB Signaling Pathway
by: A. Rimmon, et al.
Published: (2013-01-01)

Advanced mutant receptor activator of nuclear factor kappa‐Β ligand development with low affinity for osteoprotegerin
by: Yuria Jang, et al.
Published: (2025-01-01)

Conditional knockdown of hepatic PCSK9 ameliorates high-fat diet-induced liver inflammation in mice
by: Xue-Ying Zhang, et al.
Published: (2025-02-01)

Vitamin D Ameliorates Impaired Wound Healing in Streptozotocin-Induced Diabetic Mice by Suppressing Endoplasmic Reticulum Stress
by: Yi Feng Yuan, et al.
Published: (2018-01-01)

Chrysoeriol ameliorates hyperglycemia by regulating the carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats
by: Baskaran Krishnan, et al.
Published: (2020-12-01)

The Effects of Pitavastatin on Nuclear Factor-Kappa B and ICAM-1 in Human Saphenous Vein Graft Endothelial Culture
by: Bulent Demir, et al.
Published: (2019-01-01)

Severe Necrotizing Adenovirus Tubulointerstitial Nephritis in a Kidney Transplant Recipient
by: Ravi Parasuraman, et al.
Published: (2013-01-01)

Changes in the Diaphragm Lipid Content after Administration of Streptozotocin and High-Fat Diet Regime
by: Bartlomiej Lukaszuk, et al.
Published: (2017-01-01)

Nuclear Factor-Kappa B Activity Regulates Brain Expression of P-Glycoprotein in the Kainic Acid-Induced Seizure Rats
by: Nian Yu, et al.
Published: (2011-01-01)

Synthesis of pyranopyrazolo N-glycoside and pyrazolopyranopyrimidine C-glycoside derivatives as promising antitumor and antimicrobial agents
by: Hafez Hend N., et al.
Published: (2015-09-01)

EGCG improve meat quality, restore lipid metabolism disorder and regulate intestinal flora in high-fat fed broilers
by: Lujia Gao, et al.
Published: (2025-03-01)

Prediction of the Binding to the Nuclear Factor NF-Kappa-B by Constituents from <i>Teucrium polium</i> L. Essential Oil
by: Renilson Castro de Barros, et al.
Published: (2025-01-01)

A Network Pharmacology-Based Strategy for Unveiling the Mechanisms of Tripterygium Wilfordii Hook F against Diabetic Kidney Disease
by: Yuyang Wang, et al.
Published: (2020-01-01)

Novel soybean peptide iglycin ameliorates insulin resistance of high-fat diet fed C57BL/6J mice and differentiated 3T3L1 adipocytes with improvement of insulin signaling and mitochondrial function
by: Yinghuan Wu, et al.
Published: (2022-11-01)

Downregulation of Thromboxane A2 Receptor Occurs Mainly via Nuclear Factor-KappaB Signaling Pathway in Rat Renal Artery
by: Yaping Zhang, et al.
Published: (2017-01-01)

Characterisation of Pain Responses in the High Fat Diet/Streptozotocin Model of Diabetes and the Analgesic Effects of Antidiabetic Treatments
by: Frederika Maria Byrne, et al.
Published: (2015-01-01)

Surfactin alleviated hyperglycaemia in mice with type 2 diabetes induced by a high-fat diet and streptozotocin
by: Xiaoyu Chen, et al.
Published: (2023-11-01)

Free Fatty Acids Activate Renin-Angiotensin System in 3T3-L1 Adipocytes through Nuclear Factor-kappa B Pathway
by: Jia Sun, et al.
Published: (2016-01-01)

Experimental studies on cyanogenic glycosides poisoning in sheep
by: İbrahim Pirinçci, et al.

C-Glycosidic Genistein Conjugates and Their Antiproliferative Activity
by: Aleksandra Rusin, et al.
Published: (2013-01-01)

Alteration of Loperamide-Induced Prostate Relaxation in High-Fat Diet-Fed Rats
by: Sheng-Lung Hsu, et al.
Published: (2014-01-01)

Expanding Yarrowia lipolytica’s metabolic potential for detoxification of cyanogenic glycosides in edible plants
by: Fidelis Azi, et al.
Published: (2025-02-01)

The effects of Tripterygium wilfordii Hook F on renal outcomes in type 2 diabetic kidney disease patients with severe proteinuria: a single-center cohort study
by: Yaqi Cheng, et al.
Published: (2024-12-01)

Ameliorative effect of Borago officinalis L extract on sperm parameters, testosterone level in a streptozotocin-induced mouse model of diabetes
by: Nabaz abasi, et al.
Published: (2024-11-01)

MicroRNA-22 Promotes Renal Tubulointerstitial Fibrosis by Targeting PTEN and Suppressing Autophagy in Diabetic Nephropathy
by: Yingying Zhang, et al.
Published: (2018-01-01)

Blind Spot in the Radar of MEST-C Score: Type and Severity of Tubulointerstitial Nephritis in IgA Nephropathy
by: Iram Asrar, et al.
Published: (2023-01-01)