Oral administration of pioglitazone inhibits pulmonary hypertension by regulating the gut microbiome and plasma metabolome in male rats

Abstract The oral administrated thiazolidinediones (TZDs) have been widely reported to alleviate experimental pulmonary hypertension (PH). However, previous studies mainly focused on their beneficial effects on the cardiopulmonary vascular system but failed to determine their potential roles on gut...

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Bibliographic Details
Main Authors: Zizhou Zhang, Yaru Liang, Shaocong Mo, Mingming Zhao, Yi Li, Chenting Zhang, Xiaoqian Shan, Shiyun Liu, Jing Liao, Xiaoyun Luo, Junqi Zhu, Chen Wang, Qian Jiang, Chi Hou, Wei Hong, Ning Lai, Yuqin Chen, Lei Xu, Wenju Lu, Jian Wang, Zhongfang Wang, Kai Yang
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Physiological Reports
Subjects:
Online Access:https://doi.org/10.14814/phy2.70174
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