Zagociguat prevented stressor-induced neuromuscular dysfunction, improved mitochondrial physiology, and increased exercise capacity in diverse mitochondrial respiratory chain disease zebrafish models

Zagociguat prevented stressor-induced neuromuscular dysfunction, improved mitochondrial physiology, and increased exercise capacity in diverse mitochondrial respiratory chain disease zebrafish models

BackgroundZagociguat (zag) is a CNS-penetrant, soluble guanylate cyclase (sGC) stimulator that has been evaluated in phase 2a, with phase 2b ongoing, clinical studies of primary mitochondrial disease (PMD) subjects with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndr...

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Bibliographic Details
Main Authors: Leonard Burg, Heeyong Yoon, Min Peng, Peter Germano, Emily Reesey Gretzmacher, Rui Xiao, Vernon E. Anderson, Eiko Nakamaru-Ogiso, Marni J. Falk
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
soluble guanylate cyclase
mitochondrial disease
preclinical modeling
mitochondrial physiology
therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1588426/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1588426/full

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