Meningococcal Sepsis in Patient with Paroxysmal Nocturnal Hemoglobinuria during Pegcetacoplan Therapy

Meningococcal Sepsis in Patient with Paroxysmal Nocturnal Hemoglobinuria during Pegcetacoplan Therapy

Complement C5 inhibitors bring an increased risk for Neisseria infections. A novel complement C3 inhibitor, pegcetacoplan, was recently approved to treat paroxysmal nocturnal hemoglobinuria, a condition commonly treated with complement C5 inhibitors. We present a case of meningococcal sepsis in a p...

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Bibliographic Details
Main Authors: Leo Starck, Vuokko Nummi, Eira Poikonen, Anna-Elina Lehtinen, Pia Kivelä, Nathalie Friberg, Jukka Torvikoski, Maija Toropainen, Seppo Meri
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2025-03-01
Series:Emerging Infectious Diseases
Subjects:
Meningococcal
sepsis
paroxysmal nocturnal hemoglobinuria
pegcetacoplan
Neisseria meningitidis
complement
Online Access:https://wwwnc.cdc.gov/eid/article/31/3/24-1182_article
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https://wwwnc.cdc.gov/eid/article/31/3/24-1182_article

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