Effectiveness of Sofpironium Bromide in Patients with Primary Axillary Hyperhidrosis Who Experienced Residual or Recurrence of Axillary Odor after Surgery for Axillary Osmidrosis
Objectives: Sofpironium bromide is the first topical anticholinergic drug approved in Japan for the treatment of primary axillary hyperhidrosis. This study aimed to investigate the effectiveness of sofpironium bromide in patients with primary axillary hyperhidrosis who experienced residual axillary...
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| Format: | Article |
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Japan Society of Plastic and Reconstructive Surgery
2025-01-01
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| Series: | Journal of Plastic and Reconstructive Surgery |
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| Online Access: | https://www.jstage.jst.go.jp/article/jprs/4/1/4_2023-0067/_pdf/-char/en |
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| _version_ | 1832568623084863488 |
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| author | Masanobu Sakisaka Akihiko Takushima |
| author_facet | Masanobu Sakisaka Akihiko Takushima |
| author_sort | Masanobu Sakisaka |
| collection | DOAJ |
| description | Objectives: Sofpironium bromide is the first topical anticholinergic drug approved in Japan for the treatment of primary axillary hyperhidrosis. This study aimed to investigate the effectiveness of sofpironium bromide in patients with primary axillary hyperhidrosis who experienced residual axillary odor or recurrence of axillary odor after surgery with subdermal excision of apocrine glands by skin flap procedure for axillary osmidrosis.
Methods: A total of 56 patients who underwent surgery for axillary osmidrosis at our hospital between January 2022 and April 2023 were included in this study. Axillary odor and sweat volume were evaluated with patient-reported visual analog scale in 56 patients who underwent surgery for axillary osmidrosis and 13 patients administered with sofpironium bromide after the surgery.
Results: Surgery in patients with axillary osmidrosis significantly improved axillary odor and excessive sweating by approximately 90% and approximately 54%, respectively. Treatment with sofpironium bromide in patients with axillary hyperhidrosis after the surgery significantly improved axillary odor and excessive sweating by approximately 70% and approximately 63%, respectively.
Conclusions: These results suggest that sofpironium bromide is effective in patients with axillary hyperhidrosis after the surgery. Since this study was conducted with a small number of patients in a retrospective single-arm design, it is necessary to validate the results in a prospective controlled study with a large number of patients. |
| format | Article |
| id | doaj-art-238ebb43e6664d3db5d666555ae11a64 |
| institution | Kabale University |
| issn | 2436-259X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Japan Society of Plastic and Reconstructive Surgery |
| record_format | Article |
| series | Journal of Plastic and Reconstructive Surgery |
| spelling | doaj-art-238ebb43e6664d3db5d666555ae11a642025-02-03T00:52:47ZengJapan Society of Plastic and Reconstructive SurgeryJournal of Plastic and Reconstructive Surgery2436-259X2025-01-014113192023-0067Effectiveness of Sofpironium Bromide in Patients with Primary Axillary Hyperhidrosis Who Experienced Residual or Recurrence of Axillary Odor after Surgery for Axillary OsmidrosisMasanobu Sakisaka0Akihiko Takushima1Sakisaka HospitalDepartment of Plastic Surgery, Kyorin University School of MedicineObjectives: Sofpironium bromide is the first topical anticholinergic drug approved in Japan for the treatment of primary axillary hyperhidrosis. This study aimed to investigate the effectiveness of sofpironium bromide in patients with primary axillary hyperhidrosis who experienced residual axillary odor or recurrence of axillary odor after surgery with subdermal excision of apocrine glands by skin flap procedure for axillary osmidrosis. Methods: A total of 56 patients who underwent surgery for axillary osmidrosis at our hospital between January 2022 and April 2023 were included in this study. Axillary odor and sweat volume were evaluated with patient-reported visual analog scale in 56 patients who underwent surgery for axillary osmidrosis and 13 patients administered with sofpironium bromide after the surgery. Results: Surgery in patients with axillary osmidrosis significantly improved axillary odor and excessive sweating by approximately 90% and approximately 54%, respectively. Treatment with sofpironium bromide in patients with axillary hyperhidrosis after the surgery significantly improved axillary odor and excessive sweating by approximately 70% and approximately 63%, respectively. Conclusions: These results suggest that sofpironium bromide is effective in patients with axillary hyperhidrosis after the surgery. Since this study was conducted with a small number of patients in a retrospective single-arm design, it is necessary to validate the results in a prospective controlled study with a large number of patients.https://www.jstage.jst.go.jp/article/jprs/4/1/4_2023-0067/_pdf/-char/ensurgery for axillary osmidrosissubdermal excision of apocrine glandsskin flap procedureaxillary hyperhidrosissofpironium bromide |
| spellingShingle | Masanobu Sakisaka Akihiko Takushima Effectiveness of Sofpironium Bromide in Patients with Primary Axillary Hyperhidrosis Who Experienced Residual or Recurrence of Axillary Odor after Surgery for Axillary Osmidrosis Journal of Plastic and Reconstructive Surgery surgery for axillary osmidrosis subdermal excision of apocrine glands skin flap procedure axillary hyperhidrosis sofpironium bromide |
| title | Effectiveness of Sofpironium Bromide in Patients with Primary Axillary Hyperhidrosis Who Experienced Residual or Recurrence of Axillary Odor after Surgery for Axillary Osmidrosis |
| title_full | Effectiveness of Sofpironium Bromide in Patients with Primary Axillary Hyperhidrosis Who Experienced Residual or Recurrence of Axillary Odor after Surgery for Axillary Osmidrosis |
| title_fullStr | Effectiveness of Sofpironium Bromide in Patients with Primary Axillary Hyperhidrosis Who Experienced Residual or Recurrence of Axillary Odor after Surgery for Axillary Osmidrosis |
| title_full_unstemmed | Effectiveness of Sofpironium Bromide in Patients with Primary Axillary Hyperhidrosis Who Experienced Residual or Recurrence of Axillary Odor after Surgery for Axillary Osmidrosis |
| title_short | Effectiveness of Sofpironium Bromide in Patients with Primary Axillary Hyperhidrosis Who Experienced Residual or Recurrence of Axillary Odor after Surgery for Axillary Osmidrosis |
| title_sort | effectiveness of sofpironium bromide in patients with primary axillary hyperhidrosis who experienced residual or recurrence of axillary odor after surgery for axillary osmidrosis |
| topic | surgery for axillary osmidrosis subdermal excision of apocrine glands skin flap procedure axillary hyperhidrosis sofpironium bromide |
| url | https://www.jstage.jst.go.jp/article/jprs/4/1/4_2023-0067/_pdf/-char/en |
| work_keys_str_mv | AT masanobusakisaka effectivenessofsofpironiumbromideinpatientswithprimaryaxillaryhyperhidrosiswhoexperiencedresidualorrecurrenceofaxillaryodoraftersurgeryforaxillaryosmidrosis AT akihikotakushima effectivenessofsofpironiumbromideinpatientswithprimaryaxillaryhyperhidrosiswhoexperiencedresidualorrecurrenceofaxillaryodoraftersurgeryforaxillaryosmidrosis |