Targeting endoplasmic reticulum stress: an innovative therapeutic strategy for podocyte-related kidney diseases
Abstract The endoplasmic reticulum (ER) is a vital organelle responsible for protein quality control, including the folding, modification, and transport of proteins. When misfolded or unfolded proteins accumulate in the ER, it triggers endoplasmic reticulum stress (ERS) and activates the unfolded pr...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06076-3 |
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| author | Jiao Lv Honghai Yu Sasa Du Pengyu Xu Yunyun Zhao Wenxiu Qi Xiuge Wang |
| author_facet | Jiao Lv Honghai Yu Sasa Du Pengyu Xu Yunyun Zhao Wenxiu Qi Xiuge Wang |
| author_sort | Jiao Lv |
| collection | DOAJ |
| description | Abstract The endoplasmic reticulum (ER) is a vital organelle responsible for protein quality control, including the folding, modification, and transport of proteins. When misfolded or unfolded proteins accumulate in the ER, it triggers endoplasmic reticulum stress (ERS) and activates the unfolded protein response (UPR) to restore ER homeostasis. However, prolonged or excessive ERS can lead to apoptosis. The kidneys play a crucial role in maintaining physiological functions by excreting metabolic waste, regulating blood volume, balancing electrolytes and acid-base levels, and secreting various bioactive substances. Podocytes, epithelial cells situated outside the glomerular basement membrane, are essential for maintaining the structural integrity and permeability of the glomerular filtration barrier. Previous studies have shown that ERS in podocytes can contribute to the development of diseases such as glomerulonephritis, hereditary nephropathy, and diabetic kidney disease, potentially progressing to end-stage renal disease and causing patient mortality. As such, investigating ERS in podocytes has become a key area of focus in kidney disease research. This study examines recent advancements in understanding the effects of excessive ERS on podocytes across various kidney diseases, highlights the role of podocyte ERS in disease progression, and explores the potential therapeutic benefits of targeting the UPR to manage ERS in kidney diseases, thereby providing a scientific basis for clinical interventions. Graphical Abstract |
| format | Article |
| id | doaj-art-2385a01feb9b4639bd86e9a261c232ed |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-2385a01feb9b4639bd86e9a261c232ed2025-01-26T12:50:25ZengBMCJournal of Translational Medicine1479-58762025-01-0123111810.1186/s12967-025-06076-3Targeting endoplasmic reticulum stress: an innovative therapeutic strategy for podocyte-related kidney diseasesJiao Lv0Honghai Yu1Sasa Du2Pengyu Xu3Yunyun Zhao4Wenxiu Qi5Xiuge Wang6College of Chinese Medicine, Changchun University of Chinese MedicineCollege of Chinese Medicine, Changchun University of Chinese MedicineCollege of Chinese Medicine, Changchun University of Chinese MedicineCollege of Acupuncture and Moxibustion, Changchun University of Traditional Chinese MedicineEndocrinology Department, First Affiliated Hospital, Changchun University of Chinese MedicineKey Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Jilin Provincial Key Laboratory of Biomacromolecules of Chinese Medicine, Ministry of Education, Northeast Asia Research Institute of Traditional Chinese Medicine, Changchun University of Chinese MedicineEndocrinology Department, First Affiliated Hospital, Changchun University of Chinese MedicineAbstract The endoplasmic reticulum (ER) is a vital organelle responsible for protein quality control, including the folding, modification, and transport of proteins. When misfolded or unfolded proteins accumulate in the ER, it triggers endoplasmic reticulum stress (ERS) and activates the unfolded protein response (UPR) to restore ER homeostasis. However, prolonged or excessive ERS can lead to apoptosis. The kidneys play a crucial role in maintaining physiological functions by excreting metabolic waste, regulating blood volume, balancing electrolytes and acid-base levels, and secreting various bioactive substances. Podocytes, epithelial cells situated outside the glomerular basement membrane, are essential for maintaining the structural integrity and permeability of the glomerular filtration barrier. Previous studies have shown that ERS in podocytes can contribute to the development of diseases such as glomerulonephritis, hereditary nephropathy, and diabetic kidney disease, potentially progressing to end-stage renal disease and causing patient mortality. As such, investigating ERS in podocytes has become a key area of focus in kidney disease research. This study examines recent advancements in understanding the effects of excessive ERS on podocytes across various kidney diseases, highlights the role of podocyte ERS in disease progression, and explores the potential therapeutic benefits of targeting the UPR to manage ERS in kidney diseases, thereby providing a scientific basis for clinical interventions. Graphical Abstracthttps://doi.org/10.1186/s12967-025-06076-3PodocyteEndoplasmic reticulum stressApoptosisUnfolded protein responseKidney disease |
| spellingShingle | Jiao Lv Honghai Yu Sasa Du Pengyu Xu Yunyun Zhao Wenxiu Qi Xiuge Wang Targeting endoplasmic reticulum stress: an innovative therapeutic strategy for podocyte-related kidney diseases Journal of Translational Medicine Podocyte Endoplasmic reticulum stress Apoptosis Unfolded protein response Kidney disease |
| title | Targeting endoplasmic reticulum stress: an innovative therapeutic strategy for podocyte-related kidney diseases |
| title_full | Targeting endoplasmic reticulum stress: an innovative therapeutic strategy for podocyte-related kidney diseases |
| title_fullStr | Targeting endoplasmic reticulum stress: an innovative therapeutic strategy for podocyte-related kidney diseases |
| title_full_unstemmed | Targeting endoplasmic reticulum stress: an innovative therapeutic strategy for podocyte-related kidney diseases |
| title_short | Targeting endoplasmic reticulum stress: an innovative therapeutic strategy for podocyte-related kidney diseases |
| title_sort | targeting endoplasmic reticulum stress an innovative therapeutic strategy for podocyte related kidney diseases |
| topic | Podocyte Endoplasmic reticulum stress Apoptosis Unfolded protein response Kidney disease |
| url | https://doi.org/10.1186/s12967-025-06076-3 |
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