Analysis of tumor heterogeneity and cancer gene networks using deep sequencing of MMTV-induced mouse mammary tumors.

Analysis of tumor heterogeneity and cancer gene networks using deep sequencing of MMTV-induced mouse mammary tumors.

Cancer develops through a multistep process in which normal cells progress to malignant tumors via the evolution of their genomes as a result of the acquisition of mutations in cancer driver genes. The number, identity and mode of action of cancer driver genes, and how they contribute to tumor evolu...

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Main Authors: Christiaan Klijn, Marco J Koudijs, Jaap Kool, Jelle ten Hoeve, Mandy Boer, Joost de Moes, Waseem Akhtar, Martine van Miltenburg, Annabel Vendel-Zwaagstra, Marcel J T Reinders, David J Adams, Maarten van Lohuizen, John Hilkens, Lodewyk F A Wessels, Jos Jonkers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0062113&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0062113&type=printable

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