Structure and dynamics of GAD65 in complex with an autoimmune polyendocrine syndrome type 2-associated autoantibody

Structure and dynamics of GAD65 in complex with an autoimmune polyendocrine syndrome type 2-associated autoantibody

Abstract The enzyme glutamate decarboxylase (GAD) produces the neurotransmitter GABA, using pyridoxal-5’-phosphate (PLP). GAD exists as two isoforms, GAD65 and GAD67. Only GAD65 acts as a major autoantigen, frequently implicated in type 1 diabetes and other autoimmune diseases. Here we characterize...

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Main Authors: Susanne H. D. Ständer, Cyril F. Reboul, Sarah N. Le, Daniel E. Williams, Peter G. Chandler, Mauricio G. S. Costa, David E. Hoke, John D. T. Jimma, James Fodor, Gustavo Fenalti, Stuart I. Mannering, Benjamin T. Porebski, Peter Schofield, Daniel Christ, Malcolm Buckle, Sheena McGowan, Dominika Elmlund, Kasper D. Rand, Ashley M. Buckle
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57492-4
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https://doi.org/10.1038/s41467-025-57492-4

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