Unanchored simulated treatment comparison on survival outcomes using parametric and Royston-Parmar models with application to lenvatinib plus pembrolizumab in renal cell carcinoma

Unanchored simulated treatment comparison on survival outcomes using parametric and Royston-Parmar models with application to lenvatinib plus pembrolizumab in renal cell carcinoma

Abstract Background Population-adjusted indirect comparison using parametric Simulated Treatment Comparison (STC) has had limited application to survival outcomes in unanchored settings. Matching-Adjusted Indirect Comparison (MAIC) is commonly used but does not account for violation of proportional...

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Bibliographic Details
Main Authors: Christopher G. Fawsitt, Janice Pan, Philip Orishaba, Christopher H. Jackson, Howard Thom
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Medical Research Methodology
Subjects:
Simulated treatment comparison
Royston-Parmar spline models
Parametric models
Population-adjusted methods
Overall survival
Progression-free survival
Online Access:https://doi.org/10.1186/s12874-025-02480-x
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https://doi.org/10.1186/s12874-025-02480-x

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