Evolution of Functional and Paraclinical Markers as Predictive Factors in Pediatric Late-Onset SMA Under Nusinersen Treatment: The Role of CSF pNF-H

Evolution of Functional and Paraclinical Markers as Predictive Factors in Pediatric Late-Onset SMA Under Nusinersen Treatment: The Role of CSF pNF-H

Spinal Muscular Atrophy (SMA) is a rare neurodegenerative disease caused by insufficient synthesis of SMN protein, characterized by progressive muscle weakness, atrophy, and complications affecting the respiratory and digestive systems. Disease severity tends to be greater when symptoms manifest at...

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Bibliographic Details
Main Authors: Mihaela Badina, Gabriel Cristian Bejan, Corina Sporea, Andrada Mirea
Format: Article
Language:English
Published: Romanian Association of Balneology, Editura Balneara 2025-12-01
Series:Balneo and PRM Research Journal
Subjects:
spinal muscular atrophy
pnf-h neurofilaments
cerebrospinal fluid
biomarkers
predic-tive factor marker
spinraza nusinersen
creatinine
motor evolution
neurodegenerative disease
genetic mutation smn
Online Access:http://bioclima.ro/Balneo755.pdf
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http://bioclima.ro/Balneo755.pdf

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