Network pharmacology, prognostic analysis and experimental validation elucidate the therapeutic mechanism of Dingxiang Guanshitong in esophageal cancer

Abstract This study aimed to investigate the target genes of active components in Dingxiang Guanshitong (DGST) and evaluate their significance in the prognosis of esophageal cancer (EC) through integrated approaches, including network pharmacology, molecular docking, prognostic analysis, and in vitr...

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Bibliographic Details
Main Authors: Hao Zhang, Shi-qi Wang, Xiao-qi Chen, Li-qi Li, Yu-hong Zheng, Ya-ling Zhang, Xue-wen Diao, Pei-yu Yan, Yu-ling Zheng
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-00910-w
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