Application of a new highly multiplexed amplicon sequencing tool to evaluate Plasmodium falciparum antimalarial resistance and relatedness in individual and pooled samples from Dschang, Cameroon

Application of a new highly multiplexed amplicon sequencing tool to evaluate Plasmodium falciparum antimalarial resistance and relatedness in individual and pooled samples from Dschang, Cameroon

BackgroundResistance to antimalarial drugs remains a major obstacle to malaria elimination. Multiplexed, targeted amplicon sequencing is being adopted for surveilling resistance and dissecting the genetics of complex malaria infections. Moreover, genotyping of parasites and detection of molecular ma...

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Main Authors: Jacob M. Sadler, Alfred Simkin, Valery P. K. Tchuenkam, Isabela Gerdes Gyuricza, Abebe A. Fola, Kevin Wamae, Ashenafi Assefa, Karamoko Niaré, Kyaw Thwai, Samuel J. White, William J. Moss, Rhoel R. Dinglasan, Sandrine Eveline Nsango, Christopher B. Tume, Jonathan B. Parr, Innocent Mbulli Ali, Jeffrey A. Bailey, Jonathan J. Juliano
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Parasitology
Subjects:
malaria
Plasmodium falciparum
antimalarial resistance
genetic relatedness
amplicon sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fpara.2024.1509261/full
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