A young adult patient with Philadelphia positive acute lymphoblastic leukemia presenting with extreme hyperleukocytosis

A young adult patient with Philadelphia positive acute lymphoblastic leukemia presenting with extreme hyperleukocytosis

Key Clinical Message Extreme hyperleukocytosis (Leukocyte count >200 × 109/L) in an adolescent young adult (AYA) patient with B‐ALL could result in mild symptoms of leukostasis. Hyperleukocytosis requires prompt initiation of therapy with adequate hydration, cytoreduction and prevention of tumor...

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Bibliographic Details
Main Authors: Gulten Tikit, Elif Yucesu, Aliye Serpil Sarıfakıoglu, Imdat Dilek, Sule Mine Bakanay
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Clinical Case Reports
Subjects:
acute lymphoblastic leukemia (ALL)
case report
hyperleukocytosis
leukocytapheresis
leukostasis
Philadelphia (Ph+)
Online Access:https://doi.org/10.1002/ccr3.9512
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Summary:Key Clinical Message Extreme hyperleukocytosis (Leukocyte count >200 × 109/L) in an adolescent young adult (AYA) patient with B‐ALL could result in mild symptoms of leukostasis. Hyperleukocytosis requires prompt initiation of therapy with adequate hydration, cytoreduction and prevention of tumor lysis. Ph + B‐ALL may present with extreme hyperleukocytosis and may be resistant to initial pre‐phase therapy. In such cases, leukocytapheresis is beneficial in reducing the leukocyte count as well as controlling the symptoms.
ISSN:2050-0904

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