Renal Soluble Guanylate Cyclase Is Downregulated in Sunitinib‐Induced Hypertension

Renal Soluble Guanylate Cyclase Is Downregulated in Sunitinib‐Induced Hypertension

Background The tyrosine kinase inhibitor sunitinib causes hypertension associated with reduced nitric oxide (NO) availability, elevated renal vascular resistance, and decreased fractional sodium excretion. We tested whether (1) nitrate supplementation mitigates sunitinib‐induced hypertension and NO...

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Main Authors: Jeannine Witte, Melanie Mühlbauer, Diana Braun, Antje Steinbach, Janine Golchert, Rainer Rettig, Olaf Grisk
Format: Article
Language:English
Published: Wiley 2018-09-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
angiogenesis inhibitors
animal model
hypertension
kidney
nitric oxide
sodium chloride
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.118.009557
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https://www.ahajournals.org/doi/10.1161/JAHA.118.009557

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