Pain Mechanism in Rheumatoid Arthritis: From Cytokines to Central Sensitization
Pain is the most common symptom in patients with rheumatoid arthritis (RA). Although in recent years, through the implementation of targeted treatment and the introduction of disease-modifying antirheumatic drugs (DMARDs), the treatment of RA patients has made a significant progress, a large proport...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/2076328 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551239477362688 |
|---|---|
| author | Yanting Cao Danping Fan Yiqing Yin |
| author_facet | Yanting Cao Danping Fan Yiqing Yin |
| author_sort | Yanting Cao |
| collection | DOAJ |
| description | Pain is the most common symptom in patients with rheumatoid arthritis (RA). Although in recent years, through the implementation of targeted treatment and the introduction of disease-modifying antirheumatic drugs (DMARDs), the treatment of RA patients has made a significant progress, a large proportion of patients still feel pain. Finding appropriate treatment to alleviate the pain is very important for RA patients. Current research showed that, in addition to inflammation, RA pain involves peripheral sensitization and abnormalities in the central nervous system (CNS) pain regulatory mechanisms. This review summarized the literature on pain mechanisms of RA published in recent years. A better understanding of pain mechanisms will help to develop new analgesic targets and deploy new and existing therapies. |
| format | Article |
| id | doaj-art-228ac5ad8f7340f8be8da8f80cbd47a3 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-228ac5ad8f7340f8be8da8f80cbd47a32025-02-03T06:04:37ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/20763282076328Pain Mechanism in Rheumatoid Arthritis: From Cytokines to Central SensitizationYanting Cao0Danping Fan1Yiqing Yin2Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, ChinaInstitute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Anesthesiology, China-Japan Friendship Hospital, Beijing, ChinaPain is the most common symptom in patients with rheumatoid arthritis (RA). Although in recent years, through the implementation of targeted treatment and the introduction of disease-modifying antirheumatic drugs (DMARDs), the treatment of RA patients has made a significant progress, a large proportion of patients still feel pain. Finding appropriate treatment to alleviate the pain is very important for RA patients. Current research showed that, in addition to inflammation, RA pain involves peripheral sensitization and abnormalities in the central nervous system (CNS) pain regulatory mechanisms. This review summarized the literature on pain mechanisms of RA published in recent years. A better understanding of pain mechanisms will help to develop new analgesic targets and deploy new and existing therapies.http://dx.doi.org/10.1155/2020/2076328 |
| spellingShingle | Yanting Cao Danping Fan Yiqing Yin Pain Mechanism in Rheumatoid Arthritis: From Cytokines to Central Sensitization Mediators of Inflammation |
| title | Pain Mechanism in Rheumatoid Arthritis: From Cytokines to Central Sensitization |
| title_full | Pain Mechanism in Rheumatoid Arthritis: From Cytokines to Central Sensitization |
| title_fullStr | Pain Mechanism in Rheumatoid Arthritis: From Cytokines to Central Sensitization |
| title_full_unstemmed | Pain Mechanism in Rheumatoid Arthritis: From Cytokines to Central Sensitization |
| title_short | Pain Mechanism in Rheumatoid Arthritis: From Cytokines to Central Sensitization |
| title_sort | pain mechanism in rheumatoid arthritis from cytokines to central sensitization |
| url | http://dx.doi.org/10.1155/2020/2076328 |
| work_keys_str_mv | AT yantingcao painmechanisminrheumatoidarthritisfromcytokinestocentralsensitization AT danpingfan painmechanisminrheumatoidarthritisfromcytokinestocentralsensitization AT yiqingyin painmechanisminrheumatoidarthritisfromcytokinestocentralsensitization |