Review on bacterial outer membrane vesicles: structure, vesicle formation, separation and biotechnological applications
Abstract Outer membrane vesicles (OMVs), shed by Gram-negative bacteria, are spherical nanostructures that play a pivotal role in bacterial communication and host-pathogen interactions. Comprising an outer membrane envelope and encapsulating a variety of bioactive molecules from their progenitor bac...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Microbial Cell Factories |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12934-025-02653-9 |
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| _version_ | 1832585267165265920 |
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| author | Xiaofei Zhao Yusen Wei Yuqing Bu Xiaokai Ren Zhanjun Dong |
| author_facet | Xiaofei Zhao Yusen Wei Yuqing Bu Xiaokai Ren Zhanjun Dong |
| author_sort | Xiaofei Zhao |
| collection | DOAJ |
| description | Abstract Outer membrane vesicles (OMVs), shed by Gram-negative bacteria, are spherical nanostructures that play a pivotal role in bacterial communication and host-pathogen interactions. Comprising an outer membrane envelope and encapsulating a variety of bioactive molecules from their progenitor bacteria, OMVs facilitate material and informational exchange. This review delves into the recent advancements in OMV research, providing a comprehensive overview of their structure, biogenesis, and mechanisms of vesicle formation. It also explores their role in pathogenicity and the techniques for their enrichment and isolation. Furthermore, the review highlights the burgeoning applications of OMVs in the field of biomedicine, emphasizing their potential as diagnostic tools, vaccine candidates, and drug delivery vectors. |
| format | Article |
| id | doaj-art-225d156743af4b3aab72588f27e6a8e6 |
| institution | Kabale University |
| issn | 1475-2859 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Microbial Cell Factories |
| spelling | doaj-art-225d156743af4b3aab72588f27e6a8e62025-01-26T12:58:53ZengBMCMicrobial Cell Factories1475-28592025-01-0124111410.1186/s12934-025-02653-9Review on bacterial outer membrane vesicles: structure, vesicle formation, separation and biotechnological applicationsXiaofei Zhao0Yusen Wei1Yuqing Bu2Xiaokai Ren3Zhanjun Dong4Graduate School, Hebei Medical UniversityDepartment of Oncology, Hebei General HospitalDepartment of Oncology, Hebei General HospitalGraduate School, Hebei Medical UniversityGraduate School, Hebei Medical UniversityAbstract Outer membrane vesicles (OMVs), shed by Gram-negative bacteria, are spherical nanostructures that play a pivotal role in bacterial communication and host-pathogen interactions. Comprising an outer membrane envelope and encapsulating a variety of bioactive molecules from their progenitor bacteria, OMVs facilitate material and informational exchange. This review delves into the recent advancements in OMV research, providing a comprehensive overview of their structure, biogenesis, and mechanisms of vesicle formation. It also explores their role in pathogenicity and the techniques for their enrichment and isolation. Furthermore, the review highlights the burgeoning applications of OMVs in the field of biomedicine, emphasizing their potential as diagnostic tools, vaccine candidates, and drug delivery vectors.https://doi.org/10.1186/s12934-025-02653-9Outer membrane vesiclesExtracellular vesiclesGram-negative bacteriaBiotechnological applications |
| spellingShingle | Xiaofei Zhao Yusen Wei Yuqing Bu Xiaokai Ren Zhanjun Dong Review on bacterial outer membrane vesicles: structure, vesicle formation, separation and biotechnological applications Microbial Cell Factories Outer membrane vesicles Extracellular vesicles Gram-negative bacteria Biotechnological applications |
| title | Review on bacterial outer membrane vesicles: structure, vesicle formation, separation and biotechnological applications |
| title_full | Review on bacterial outer membrane vesicles: structure, vesicle formation, separation and biotechnological applications |
| title_fullStr | Review on bacterial outer membrane vesicles: structure, vesicle formation, separation and biotechnological applications |
| title_full_unstemmed | Review on bacterial outer membrane vesicles: structure, vesicle formation, separation and biotechnological applications |
| title_short | Review on bacterial outer membrane vesicles: structure, vesicle formation, separation and biotechnological applications |
| title_sort | review on bacterial outer membrane vesicles structure vesicle formation separation and biotechnological applications |
| topic | Outer membrane vesicles Extracellular vesicles Gram-negative bacteria Biotechnological applications |
| url | https://doi.org/10.1186/s12934-025-02653-9 |
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