Cryo-EM structure of an activated GPR4–Gs signaling complex

Cryo-EM structure of an activated GPR4–Gs signaling complex

Abstract G protein-coupled receptor 4 (GPR4) belongs to the subfamily of proton-sensing GPCRs (psGPCRs), which detect pH changes in extracellular environment and regulate diverse physiological responses. GPR4 was found to be overactivated in acidic tumor microenvironment as well as inflammation site...

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Main Authors: Yitong Ma, Yijie Wang, Mengyuan Tang, Yuan Weng, Ying Chen, Yueming Xu, Shuxiao An, Yiran Wu, Suwen Zhao, Huanhuan Xu, Dali Li, Mingyao Liu, Weiqiang Lu, Heng Ru, Gaojie Song
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-55901-2
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https://doi.org/10.1038/s41467-025-55901-2

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