A review of biodegradable biliary stents made of magnesium metals: Current progress and future trends
Biliary system, which is responsible for transporting bile from the liver into the intestine, is commonly damaged by inflammation or tumors eventually causing liver failure or death. The implantation of biliary stents can effectively alleviate both benign and malignant biliary strictures, but the pl...
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KeAi Communications Co., Ltd.
2025-01-01
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| Series: | Journal of Magnesium and Alloys |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213956724003748 |
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| author | Ling Liu Tuo En Liu Tan To Cheung |
| author_facet | Ling Liu Tuo En Liu Tan To Cheung |
| author_sort | Ling Liu |
| collection | DOAJ |
| description | Biliary system, which is responsible for transporting bile from the liver into the intestine, is commonly damaged by inflammation or tumors eventually causing liver failure or death. The implantation of biliary stents can effectively alleviate both benign and malignant biliary strictures, but the plastic and metal stents that are currently used cannot degrade and nearly has no beneficial biological effects, therefore their long-term service can result into inflammation, the formation of sludges and re-obstruction of bile duct. In recent years, magnesium (Mg) metal has been received increasing attention in the field of biomedical application due to its excellent biocompatibility, adequate mechanical properties, biodegradability and other advantages, such as anti-inflammatory and anti-tumor properties. The research on biliary stents made of magnesium metals (BSMM) has also made significant progress and a series of experiments in vitro and vivo has proved their possibility. However, there are still some problems holding back BSMM's clinical use, including rapid corrosion rate and potential harmful reaction. In this review, we would summarize the current research of BSMM, evaluate their clinical benefits, find the choke points, and discuss the solving method. |
| format | Article |
| id | doaj-art-21ff860cd7384c7ab4e6e9d01e0ad529 |
| institution | Kabale University |
| issn | 2213-9567 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Magnesium and Alloys |
| spelling | doaj-art-21ff860cd7384c7ab4e6e9d01e0ad5292025-02-06T05:11:42ZengKeAi Communications Co., Ltd.Journal of Magnesium and Alloys2213-95672025-01-011313040A review of biodegradable biliary stents made of magnesium metals: Current progress and future trendsLing Liu0Tuo En Liu1Tan To Cheung2Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road 102, Hong Kong Special Administrative Region; State Key Laboratory of Advanced Design andManufacturing Technology for Vehicle, Hunan University, Changsha 410012, PR China; Department of biliary Surgery, Xiangya Hospital of Central South University, Changsha 410008, PR China; International Joint Research Center of Minimally Invasive Endoscopic Technology Equipment & Standards, Xiangya Hospital of Central South University, Changsha 410008, PR China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha 410008, PR ChinaDepartment of Biomedical Sciences, West Virginia School of Osteopathic Medicine, Lewisburg WV 24901, United StatesDepartment of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road 102, Hong Kong Special Administrative Region; Corresponding author.Biliary system, which is responsible for transporting bile from the liver into the intestine, is commonly damaged by inflammation or tumors eventually causing liver failure or death. The implantation of biliary stents can effectively alleviate both benign and malignant biliary strictures, but the plastic and metal stents that are currently used cannot degrade and nearly has no beneficial biological effects, therefore their long-term service can result into inflammation, the formation of sludges and re-obstruction of bile duct. In recent years, magnesium (Mg) metal has been received increasing attention in the field of biomedical application due to its excellent biocompatibility, adequate mechanical properties, biodegradability and other advantages, such as anti-inflammatory and anti-tumor properties. The research on biliary stents made of magnesium metals (BSMM) has also made significant progress and a series of experiments in vitro and vivo has proved their possibility. However, there are still some problems holding back BSMM's clinical use, including rapid corrosion rate and potential harmful reaction. In this review, we would summarize the current research of BSMM, evaluate their clinical benefits, find the choke points, and discuss the solving method.http://www.sciencedirect.com/science/article/pii/S2213956724003748Biliary stentsMagnesium metalsDegradationBiological application |
| spellingShingle | Ling Liu Tuo En Liu Tan To Cheung A review of biodegradable biliary stents made of magnesium metals: Current progress and future trends Journal of Magnesium and Alloys Biliary stents Magnesium metals Degradation Biological application |
| title | A review of biodegradable biliary stents made of magnesium metals: Current progress and future trends |
| title_full | A review of biodegradable biliary stents made of magnesium metals: Current progress and future trends |
| title_fullStr | A review of biodegradable biliary stents made of magnesium metals: Current progress and future trends |
| title_full_unstemmed | A review of biodegradable biliary stents made of magnesium metals: Current progress and future trends |
| title_short | A review of biodegradable biliary stents made of magnesium metals: Current progress and future trends |
| title_sort | review of biodegradable biliary stents made of magnesium metals current progress and future trends |
| topic | Biliary stents Magnesium metals Degradation Biological application |
| url | http://www.sciencedirect.com/science/article/pii/S2213956724003748 |
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