IFN-β production induced by PRRSV is affected by GP3 quantity control and CLND4 interaction

IFN-β production induced by PRRSV is affected by GP3 quantity control and CLND4 interaction

Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most harmful pathogens in the swine industry. Our previous studies demonstrated that the small extracellular domain (ECL2) of CLDN4 effectively blocks PRRSV infection. In this study, we explored the in vivo administra...

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Bibliographic Details
Main Authors: Dexin Li, Xinyu Cui, Yingchao Li, Qin Zhang, Hongyan Gao, Youbo Li, Yanmeng Hou, Hongjie Yuan, Yihong Xiao
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Veterinary Research
Subjects:
CLDN4
GP3
IFN-β
PRRSV
sECL2
Online Access:https://doi.org/10.1186/s13567-025-01455-6
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