HLA-Bw4 in association with KIR3DL1 favors natural killer cell-mediated protection against severe COVID-19

HLA-Bw4 in association with KIR3DL1 favors natural killer cell-mediated protection against severe COVID-19

Replicating SARS-CoV-2 has been shown to degrade HLA class I on target cells to evade the cytotoxic T-cell (CTL) response. HLA-I downregulation can be sensed by NK cells to unleash killer cell immunoglobulin-like receptor (KIR)-mediated self-inhibition by the cognate HLA-I ligands. Here, we investig...

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Bibliographic Details
Main Authors: Ruihua Wang, Ying Sun, Bo-Hua Kuang, Xiao Yan, Jinju Lei, Yu-Xin Lin, Jinxiu Tian, Yating Li, Xiaoduo Xie, Tao Chen, Hui Zhang, Yi-Xin Zeng, Jincun Zhao, Lin Feng
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Emerging Microbes and Infections
Subjects:
COVID-19
SARS-CoV-2
NK cells
Bw4 epitope
HLA-KIR interaction
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2023.2185467
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https://www.tandfonline.com/doi/10.1080/22221751.2023.2185467

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