Defective Olfactomedin-2 connects adipocyte dysfunction to obesity

Defective Olfactomedin-2 connects adipocyte dysfunction to obesity

Abstract Olfactomedin-2 (OLFM2) is a pleiotropic glycoprotein emerging as a regulator of energy homeostasis. We here show the expression of OLFM2 to be adipocyte-specific and inversely associated with obesity. OLFM2 levels increase during adipogenesis and are suppressed in inflamed adipocytes. Funct...

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Main Authors: Aina Lluch, Jèssica Latorre, Isabel Espadas, Núria Oliveras-Cañellas, José M. Moreno-Navarrete, Estefanía Caballano-Infantes, Gitalee Sarker, Nicolás F. Malvido, Pablo Garrido-Gil, José L. Labandeira-García, Naoki Nakaya, Silvia Mora, Eduardo Chicano, Jaime López-Alcalá, María M. Malagón, Alejandro Martín-Montalvo, Birong Zhang, You Zhou, Ana I. Domingos, Miguel López, Johanna Pörschke, María Gómez-Serrano, Witold Szymanski, Johannes Graumann, Stanislav I. Tomarev, Ismael González-García, José M. Fernández-Real, Francisco J. Ortega
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62430-5
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